生长抑素联合泮托拉唑治疗上消化道大出血的疗效观察及药理作用

Observation on the therapeutic effect and pharmacological effect of somatostatin combined with pantoprazole in the treatment of upper gastrointestinal hemorrhage

目的研究泮托拉唑与生长抑素联合治疗上消化道大出血的临床疗效及药理作用。方法选择2017年12月~2018年12月在我院进行治疗的上消化道大出血患者90例作为观察对象,按随机数字分组方式将患者分为研究组(n=45)和对照组(n=45)。两组患者均采取常规对症治疗,对照组使用泮托拉唑治疗,研究组则使用泮托拉唑联合生长抑素治疗,观察对比两组患者临床疗效、临床各项指标改善情况以及不良反应发生情况。结果研究组患者临床治疗总有效率明显高于对照组,差异有统计学意义(P<0.05);研究组患者止血时间、肠鸣音恢复时间以及住院时间明显优于对照组,差异有统计学意义(P<0.05);两组患者不良反应发生情况比较,差异无统计学意义(P>0.05)。结论泮托拉唑联合生长抑素用于治疗上消化道大出血临床效果确切,止血时间更快,肠鸣音恢复时间更早,缩短住院时间,安全性良好,可在临床治疗中借鉴应用。

Objective To study the clinical efficacy and pharmacological effects of pantoprazole combined with somatostatin in the treatment of upper gastrointestinal hemorrhage. Methods A total of 90 patients with upper gastrointestinal hemorrhage who were treated in our hospital from December 2017 to December 2018 were selected as subjects. The patients were divided into study group(n=45) and control group(n=45) by random number grouping. Both groups of patients were given conventional symptomatic treatment. The control group was given pantoprazole, and the study group was given pantoprazole combined with somatostatin. The clinical efficacy, improvement of clinical indicators and occurrence of adverse reactions were observed and compared between the two groups. Results The total effective rate of clinical treatment in the study group was significantly higher than that in the control group, and the difference between the groups was statistically significant(P<0.05);the hemostasis time, recovery time of bowel sounds and length of stay in the study group were significantly better than those in the control group, and the difference between the two groups was statistically significant(P<0.05);there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion Pantoprazole combined with somatostatin is effective in the clinical treatment of upper gastrointestinal hemorrhage, with faster hemostasis, faster recovery time of bowel sounds, shorter length of hospital stay and good safety, which is worthy of promotion and application in clinical treatment.