中西医结合序贯疗法治疗痰湿阻滞型多囊卵巢综合征的疗效

Therapeutic effect of sequential therapy with integrated traditional Chinese and Western medicine in the treatment of phlegm-dampness and blood stasis type polycystic ovary syndrome

目的探讨中西医结合序贯疗法治疗痰湿阻滞型多囊卵巢综合征的疗效。方法选取我院妇科门诊2016年8月~2017年5月期间就诊的60例痰湿阻滞型多囊卵巢综合征患者,将其随机分为对照组和治疗组,每组30例,前者给予克罗米芬、绒促性素治疗,后者在此基础上给予中药序贯疗法,比较两组患者在体重指数、空腹血糖、空腹胰岛素、血清性激素水平及子宫内膜厚度、最大卵泡直径、排卵率等方面的差异。结果治疗前两组患者体重指数比较,差异无统计学意义(P>0.05),治疗后,两组均改善显著(P<0.05),治疗组BMI下降与对照组比较有显著性差异(P<0.05)。治疗前两组患者性激素水平比较,差异无统计学意义(P>0.05),治疗后,两组患者性激素水平均有所改善,且治疗组改善较为显著(P<0.05),治疗组性激素水平变化较对照组有显著性差异(P<0.05)。治疗前两组患者空腹胰岛素及空腹血糖指标比较,差异无统计学意义(P>0.05),治疗后,两组患者空腹胰岛素水平及空腹血糖指标均有所改善,且治疗组改善较为显著(P<0.05),治疗组空腹胰岛素水平及空腹血糖指标较对照组有明显下降(P<0.05)。治疗前两组患者子宫内膜厚度、最大卵泡直径、排卵率比较,差异无统计学意义(P>0.05),且治疗后,两组子宫内膜厚度、最大卵泡直径、排卵率均有所改善,且治疗组改善较为显著(P<0.05),治疗组子宫内膜厚度、最大卵泡直径、排卵率变化较对照组有显著性差异(P<0.05)。结论中西医结合序贯疗法在降低体重指数、改善性激素紊乱水平、降低胰岛素抵抗、增加卵泡体积、增加子宫内膜厚度、促进排卵方面有显著效果,值得临床推广。

Objective To investigate the efficacy of sequential therapy with integrated traditional Chinese and western medicine in the treatment of phlegm-dampness and blood stasis type polycystic ovary syndrome. Methods 60 patients with phlegm-dampness and blood stasis polycystic ovary syndrome who were admitted to the outpatient clinic of gynecology in our hospital from August 2016 to May 2017 were selected. They were randomly divided into control group and treatment group, with 30 cases in each group. The former was given clomiphene and chorionic gonadotropin for treatment, and the latter was given sequential therapy of traditional Chinese medicine on this basis. The differences in body mass index, fasting blood glucose, fasting insulin, serum sex hormone levels and endometrial thickness, maximum follicle diameter, and ovulation rate were compared between the two groups. Results The difference in body mass index between the two groups before treatment was not statistically significant(P>0.05). After treatment, both groups were improved significantly(P<0.05). There was a significant difference in the BMI decrease between the treatment group and the control group(P<0.05). There was no statistically significant difference in sex hormone levels between the two groups before treatment(P>0.05). After treatment, the levels of sex hormones were improved in both groups, and the improvement in the treatment group was significant(P<0.05). The changes of sex hormone levels in the treatment group were significantly different from those in the control group(P<0.05). There was no statistically significant difference in FINS and FPG between the two groups before treatment(P>0.05). After treatment, FINS and FPG of the two groups were improved, and the improvement in the treatment group was more significant (P<0.05). The FINS and FPG in the treatment group were significantly lower than those in the control group (P<0.05). there was no statistically significant difference in endometrial thickness, maximum follicular diameter, and ovulation rate between the two groups before treatment(P>0.05). After treatment, the endometrial thickness, maximum follicular diameter and ovulation rate in the two groups were improved, and the improvement in the treatment group was more significant(P<0.05). The changes of endometrial thickness, maximum follicular diameter and ovulation rate in the treatment group were significantly different from those in the control group (P<0.05). Conclusion Sequential therapy with integrated Chinese and Western medicine has significant effects in reducing body mass index, improving sex hormone disorder level, reducing insulin resistance, increasing follicular volume, increasing endometrial thickness and promoting ovulation, which is worthy of clinical promotion.