肠道菌群对动脉粥样硬化发病的影响及机制

Effect of intestinal flora on the pathogonesis of atherosclerosis and its mechanism

动脉粥样硬化是最常见的心血管系统疾病,以脂质和复合糖类在动脉内壁的异常聚集为特征,涉及一系列代谢和炎症反应。动脉粥样硬化的发病机制非常复杂,最近研究发现肠道菌群可通过对宿主代谢和炎症的调节影响动脉粥样硬化的进程,因此受到广泛关注。本文通过对近年来关于肠道菌群和动脉粥样硬化的关系研究进展进行回顾,系统介绍肠道菌群微生态对动脉粥样硬化发病的影响,探讨了肠道菌群调节动脉粥样硬化的潜在机制,益生菌的补给对动脉粥样硬化的治疗益处以及通过调节肠道菌群预防和延缓动脉粥样硬化的方法。

Atherosclerosis,the most common cardiovascular disease characterized by abnormal accumulation of lipids and complex carbohydrate in the arterial wall,involves a series of metabolic and inflammatory reactions. The pathogenesis of atherosclero. sis is very complex. Recent studies have found that gut microbiota can influence the progress of atherosclerosis via regulating host metabolism and inflammation,which has attracted broad attention. In this paper,we review the recent research progress in the relation. ship between intestinal flora and atherosclerosis,systematically introduce the influence of intestinal microflora in the pathogenesis of atherosclerosis,and explore the underlying mechanisms by which intestinal flora regulates atherosclerosis,the therapeutic benefits of probiotic supplementation for atherosclerosis,and the prevention and delay of atherosclerosis by regulating intestinal flora.