APT在胶质瘤假性进展与复发鉴别中的应用

Differentiating pseudoprogression from recurrence in patients with gliomas using amide proton transfer imaging

目前,高级别胶质瘤术后常辅以放疗或同步放化疗。治疗后呈现的假性进展与肿瘤复发在常规MRI中表现极为相似,两者在临床上难于鉴别。酰胺质子转移(APT)技术通过检查组织中的酰胺质子含量对鉴别两者有较高的敏感性和特异性。就APT在胶质瘤假性进展与复发鉴别中的应用,以及相比动态磁敏感对比增强灌注加权成像(DSC-PWI)、磁共振波谱成像(MRS)、PET技术的优势予以综述。

Currently, radiotherapy or concurrent chemoradiation is often used as an adjunct method in the treatment of patients with high-grade gliomas(HGG) after surgery. Distinguishing treatment-related imaging changes such as pseudoprogression from tumor recurrence is difficult due to extremely similar appearances on conventional MRI. Amide proton transfer(APT) imaging have relatively high sensitivity and specificity to distinguish pseudoprogression from tumor recurrence by examining the content of amide proton in tissue. This paper reviews the APT in differentiating pseudoprogression from recurrence of gliomas and its advantages compared with DSC-PWI, MRS, and PET.