化学交换饱和转移在中枢神经系统中的应用进展

Application advances of chemical exchange saturation transfer in central nervous system

中枢神经系统疾病发生发展过程中常伴有组织内蛋白质、葡萄糖、谷氨酸、肌酸等内源性代谢物含量或浓度的改变。化学交换饱和转移(CEST)成像通过检测这些代谢物的变化,实现脑肿瘤、脑梗死、脑损伤、神经退行性疾病等的早期诊断及疗效评估。就化学交换饱和转移成像的基本原理及其在中枢神经系统中的应用进展、制约因素和发展前景予以综述。

When central nervous system diseases occur, the content or concentration of endogenous metabolites,such as protein, glucose, glutamate, and creatine, in the tissue will change. The early diagnosis and monitoring treatment in brain tumor, cerebral infarction, brain injury, and degenerative diseases can be achieved by using chemical exchange saturation transfer(CEST) imaging to detect the changes of these metabolites. In this article, the basic principle, applications in central nervous system, constraints, and development prospects of CEST imaging were reviewed.