细粒棘球绦虫基因多态性的研究进展

Advances in the genetic polymorphism of Echinococcus granulosus

细粒棘球绦虫的幼虫寄生于中间宿主(人、牛、羊等)肝、肺等脏器后发展成包囊,压迫、刺激宿主脏器,引起细粒棘球黝病,严重危害人体健康和畜牧业发展。全球患细粒棘球熾病的人数超过100万,被世界卫生组织列为要求重点关注的热带病之一。随着分子生物学技术的发展,目前把细粒棘球绦虫分为9个基因型(G1、G3-G8、G10和狮株),每种基因型的地区分布、宿主种类、致病性等不尽相同。该综述主要对全球细粒棘球绦虫基因多态性的研究进展进行综述,并对发展方向进行展望,为进一步开展细粒棘球坳病防治研究提供数据支撑。

The larvae of Echinococcus granulosus parasitize in the liver and lungs of the intermediate host (human, cattle, sheep, etc.) and develop into cysts that damage the organs and cause hydatidosis. The disease is still a seriously public health problem that threats the health of people and hurdles the animal husbandry in the endemic areas. It is estimated that more than 1 million people are suffering from hydatidosis, listed as one of serious tropical diseases by the World Health Organization. Based on the genetic variation E. granulosus has been classified into 9 genotypes (G1, G3-G8, G10 and E. felidis) that differ in the regional distribution, host species and pathogenicity. This review focuses on the research progress on the genetic polymorphism of E. granulosus and research direction, providing supporting data for better understanding and control of hydatidosis.