玉黄膏治疗斑块状银屑病血瘀证的临床疗效及影响因素分析

Clinical Effect of Yuhuang Ointment on Plaque Psoriasis Patients with TCM Pattern of Blood Stasis

目的研究玉黄膏治疗斑块状银屑病血瘀证的疗效特点及优势,以及不同血清补体C3水平对玉黄膏疗效的影响。方法采用对照研究方法,以53例斑块状银屑病血瘀证的门诊患者为研究对象,并按照患者外周血血清补体C3水平,把研究对象分成正常补体组及低补体组两组,全部给予玉黄膏规范化治疗4周,治疗结束后比较两组研究对象的临床疗效以及不同补体C3水平下的疗效差异。结果玉黄膏能够有效减轻斑块状银屑病的皮损厚度及皮损严重程度分数(PASI分数),停药后药物延续作用可以长达4周。虽然不同血清补体C3水平对于玉黄膏治疗斑块状银屑病的临床疗效无影响,但低补体C3水平更易导致疾病复发,并在一定程度上影响了玉黄膏的抗增殖作用。结论玉黄膏治疗斑块状银屑病血瘀证患者有效,而不同血清补体C3水平一定程度上影响了玉黄膏的治疗效果,其机制有待进一步去深入研究。

Objective To evaluate the clinical effectiveness and the effect of C3 level on Yuhuang ointment in plaque psoriasis patients with TCM pattern of blood stasis.Methods A total of 53 plaque psoriatic outpatients with TCM pattern of blood stasis was divided into normal C3 level group and the lower C3 level group.Both two groups were given Yuhuang ointment twice a day for one month.At the second and fourth week of treatment,the clinical efficacy between two groups were evaluated.Results The clinical effectiveness of Yuhuang ointment could not be affected by different C3 level.However,the lower level of C3 leaded to relapses easily,and the anti-proliferative effects of Yuhuang ointment were affected by lower C3 level.Conclusion Yuhuang ointment have efficacy in treatment plaque psoriasis.The C3 level has a certain affect on the benefits of the drug.The exact mechanism needs further investigation.