基于蛋白质组学技术的细菌耐药性研究进展

Progress on Bacterial Resistance Based on Proteomics Technology

日益严重的细菌耐药性问题给全球公共卫生带来极大威胁。蛋白质组学作为后基因组学的重要组成部分,其主要技术体系得到了快速发展并逐渐成熟。应用蛋白质组学技术对耐药细菌展开研究,可以阐明细菌耐药性的发生机制,并且使大规模寻找抗菌药物作用靶点成为可能。论文概述了蛋白质组学技术体系在细菌耐药性机制研究方面的应用,以期为深入阐明细菌耐药机制及研发新型抗耐药菌药物提供新思路。

The growing problem of bacterial resistance poses a great threat to global public health.Proteomics,as an important part of post-genomics,its main technical system has been developed rapidly and matured gradually.Proteomic study of drug-resistant bacteria can clarify the mechanism of bacterial resistance and make it possible to find the target of antimicrobial action on a large scale.This paper summarized the application of proteomics technology system in the study of bacterial resistance mechanism in order to providing a new idea for further elucidating bacterial resistance mechanism and developing new antibacterials.