摘要
日益严重的细菌耐药性问题给全球公共卫生带来极大威胁。蛋白质组学作为后基因组学的重要组成部分,其主要技术体系得到了快速发展并逐渐成熟。应用蛋白质组学技术对耐药细菌展开研究,可以阐明细菌耐药性的发生机制,并且使大规模寻找抗菌药物作用靶点成为可能。论文概述了蛋白质组学技术体系在细菌耐药性机制研究方面的应用,以期为深入阐明细菌耐药机制及研发新型抗耐药菌药物提供新思路。
The growing problem of bacterial resistance poses a great threat to global public health.Proteomics,as an important part of post-genomics,its main technical system has been developed rapidly and matured gradually.Proteomic study of drug-resistant bacteria can clarify the mechanism of bacterial resistance and make it possible to find the target of antimicrobial action on a large scale.This paper summarized the application of proteomics technology system in the study of bacterial resistance mechanism in order to providing a new idea for further elucidating bacterial resistance mechanism and developing new antibacterials.
作者
郭玉茹
裘鹏
苏鸿雨
高翔
张德显
张路遥
刘明春
GUO Yuru;QIU Peng;SU Hong-yu;GAO Xiang;ZHANG De-xian;ZHANG Luyao;LIU Ming-chun(College of Animal Husbandry and Veterinary Medicine, Shenyang Agricultural University, Shenyang, Liaoning,110866, China)
出处
《动物医学进展》
北大核心
2019年第9期89-92,共4页
Progress In Veterinary Medicine
基金
国家自然科学基金项目(31572564,31772795)
关键词
蛋白质组学
细菌
耐药性
机制
靶点
proteomics
bacteria
drug resistance
mechanism
target