高敏心肌肌钙蛋白T在新生儿疾病中的临床应用进展

A review on the clinical application of high-sensitivity cardiac troponin T in neonatal diseases

目的高敏心肌肌钙蛋白T (hs-cTnT)近些年已成为在成人中公认有效的心肌损伤标记物,可以诊断急性心肌损伤,并对心血管不良事件有良好的预测作用;是诊断成人急性心肌坏死的金标准。新生儿是一个特殊群体,其在围生期各种生理过程变化,导致很多实验室检测指标并不能像成人那样,有较好的临床应用价值。例如迄今为止还没有一个比较合适的心脏血清生物标记物能够反映新生儿心肌损伤的真实情况。近些年国内外对于hs-cTnT在新生儿领域中的应用价值的探讨有了新的突破。为了能够全面了解hs-cTnT在新生儿疾病中的作用,该文对hs-cTnT的生物学、生理学特性及其在新生儿领域中的应用进展等进行综述。

In recent years, high-sensitivity cardiac troponin T (hs-cTnT) has been recognized as an effective marker for myocardial injury in adults and can be used to diagnose acute myocardial injury and predict major adverse cardiovascular events. It is the gold standard for the diagnosis of acute myocardial infarction in adults. Neonates are a special group, and due to the changes of various physiological processes during the perinatal period, many laboratory markers used in adults may have a low clinical value in neonates. So far, for example, there is still no suitable cardiac serum biomarker that can reflect the true condition of neonatal myocardial injury. In recent years, new breakthroughs have been made in the application of hs-cTnT in the field of neonates. In order to fully understand the role of hs-cTnT in neonatal diseases, this article reviews the research advances in the biological and physiological features of hs-cTnT and its application in neonates.