河南省东北部地区成年男性25羟维生素D水平与性激素和心血管危险因素的相关性分析

25-hydroxyvitamin D, sex hormone levels and cardiovascular risk among men in northeast area of Henan province

目的探讨河南省东北部地区成年男性25羟维生素D[25(OH)D]水平与性激素和心血管疾病危险因素的相关性。方法2015年12月至2016年3月,采用多阶段分层整群随机抽样法从甲状腺疾病和糖尿病全国调查-2014(TIDE)河南分中心调查队列中抽取697例男性受试者,采用线性回归分析探讨25(OH)D与性激素和心血管危险因素的相关性。结果受试者的年龄为19~85(46.6±15.9)岁。维生素D缺乏、不足、正常的比例分别为9.3%、13.1%和77.6%。城市居民维生素D缺乏率明显高于农村居民(13.3%比5.7%,P=0.001)。校正了年龄、城乡分布、经济状态、教育、体重指数(BMI)、腰围、稳态模型评估胰岛素抵抗指数(HOMA-IR)、高血压、糖尿病、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)和尿酸后,25(OH)D每增加25 nmol/L,lg FT(FT为游离睾酮)增加0.013 ng/L(β=0.013,P=0.036),lg DHT(DHT为双氢睾酮)增加0.030 ng/L(β=0.030,P=0.019),lg AD(AD为雄烯二酮)增加0.019 μg/L(β=0.019,P=0.008)。校正了年龄、城乡分布、经济状态和学历后,25(OH)D每增加25 nmol/L,糖化血红蛋白(HbA1c)降低0.051%(β=-0.051,P=0.027)。结论高维生素D水平与高FT、高DHT、高AD及低HbA1c相关。

Objective To examine associations of 25-hydroxyvitamin D [25(OH)D] concentrations with sex hormone levels and cardiovascular risk factors. Methods A total of 697 male subjects were obtained from the thyroid disorders, lodine status and diabetes: a national epidemiological survey-2014 (TIDE) research--Henan sub-center survey through multistage stratified cluster random sampling from December 2015 to March 2016. The associations between 25(OH)D and sex hormones or cardiovascular risk factors were analyzed by linear regression analyses. Results The age of the subjects was (46.6±15.9) years (19-85 years). Proportions of vitamin D deficient, vitamin D intermediate and vitamin D optimal were 9.3%, 13.1% and 77.6%, respectively. More subjects with vitamin D deficient were in urban area than in rural area (13.3% vs. 5.7%, P=0.001). After fully adjusting for age, residence area, economic status, education, body mass index, waist circumference, homeostasis model assessment of insulin resistance (HOMA-IR), hypertension, diabetes, triglyceride, high-density lipoproteincholesterol, total cholesterol, low-density lipoprotein cholesterol and uric acid, linear regression analyses showed that every 25 nmol/L increase in 25(OH)D levels increased lg FT(FT=free testosterone) by 0.013ng/L (β=0.013, P=0.036), lg DHT (DHT=dihydrotestosterone) by 0.030 ng/L (β=0.030, P=0.019), and lg AD (AD=androstenedione) by 0.019 μg/L (β=0.019, P=0.008). After fully adjusting for age, residence area, economic status and education, every 25 nmol/L increase in 25(OH)D levels lowered glycosylated hemoglobin A1c (HbA1c) by 0.051%(β=-0.051, P=0.027). Conclusions Higher 25(OH)D concentrations in men were associated with higher FT, DHT, AD and lower HbA1c levels.