光声弹性成像技术在动脉血压监测中的应用研究

Application of Photoacoustic Elastography Technique in Arterial Blood-Pressure Monitoring

基于血管弹性成像原理,利用光声成像技术测量不同压力作用下血管内径的变化情况,通过建立光声信号的时域特征模型,计算用于分析血压-管径特征关系的信息,再结合希尔伯特变换等数字信号处理方法进行分析,由此获得了组织中弹性力学性质的空间分布情况。实验结果表明:压力、血管管径与光声信号峰峰值的时间间隔呈单调递增的关系,该技术可用于快速、实时地检测血管直径的变化,为光声成像技术实现非侵入式动态血压测量提供了理论依据。

Based on the angio elastography principle,the variation in blood-vessel diameter with pressure is measured by the photoacoustic elastography technique.A characteristic time-domain model for photoacoustic signals is developed to analyze the information of the blood pressure-diameter relation.A series of digital signal-processing methods based on the Hilbert transform are used to obtain spatial distributions of elastic mechanical properties in tissues.Results demonstrate that the pressure and vessel diameter have a monotonously increasing relation with the photoacoustic-signal time interval,which can be used to dynamically and quickly detect changes in the vessel diameter.This method provides a theoretical basis for non-invasive ambulatory blood-pressure measurements by photoacoustic imaging.