关注非传统危险因子在心血管疾病残余风险评估中的作用

Focus on residual cardiovascular disease risk, re-recognizing non-traditional risk factors

心血管疾病(CVD)残余风险通常指按已有的指南防治后,低密度脂蛋白胆固醇(LDL-C)达标,血压和血糖得到控制,但CVD事件风险依然存在.因此,在控制传统危险因素的同时,不断发现CVD残余风险,对进一步降低CVD事件至关重要.已发现脂蛋白(a)、富含甘油三酯的脂蛋白(TRLs)及其残余物、高密度脂蛋白胆固醇(HDL-C)、超敏C反应蛋白(hs-CRP)和同型半胱氨酸(HCY)水平是CVD残余风险因子;基因相关因素以及一些新的非传统的因素是否可以预测CVD的残余风险也已成为研究的热点.关注心血管疾病的残余风险因子,可为进一步降低CVD事件提供新的思路.

The residual cardiovascular disease (CVD) risk is the term applied to the cardiovascular events remain prevalent among individuals with low or normal LDL-C, normal blood pressure and glucose. Therefore, while controlling traditional risk factors, the CVD residual risk is constantly being discovered, which is crucial for further reducing CVD events. Lipoprotein (a), TRLs and their residues, HDL-C, hypersensitive CRP and homocysteine have been found to be CVD residual risk factors. Whether gene-related factors and some new non-traditional factors can predict residual CVD risk have also become the current research hotspots. Focusing on the residual risk factors of cardiovascular disease can provide new ideas for further reducing CVD events.