鼻咽癌放疗继发外耳道癌影响因素初步分析

Preliminary analysis of the factors influencing the secondary external auditory canal carcinoma of nasopharyngeal cancer

目的初步分析放疗后继发外耳道癌(RIEACC)患者临床特征和影响发病的因素。方法回顾分析1990-2017年间确诊RIEACC的16例患者病例资料,应用Logistic回归分析影响发病的因素。结果单因素分析显示患者年龄、吸烟史、肿瘤家族史、分期是影响放疗后发生RIEACC的因素;而多因素分析显示年龄、肿瘤家族史、鼻咽癌分期是影响放疗后发生RIEACC危险因素。结论RIEACC是鼻咽癌放疗后的少见并发症,初步证明年龄、肿瘤家族史、鼻咽癌分期是主要影响因素,虽然发病率低但恶性程度高应高度警惕。

Objective In order to investigate the clinical features and influence factors for incidence in patients with radiation-induced external auditory canal carcinoma (RIEACC). Methods The nasopharyngeal carcinoma (NPC) 16 patients who were diagnosised RIEACC after radiotherapy in the Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University from January 1990 to December 2017 were retrospectively analysis. The influence factors analysis were used Logistic regression analysis. Results Univariate analysis showed that age, somking history, family history of cancer and NPC stage were the influencing factors. Multi-factor logistic regression analysis showed that age, family history of cancer and NPC stage were independent risk factors. Conclusions RIEACC is rare complication of NPC patients received radiotherapy, which is also a multifactorial outcome. Age, family history of cancer and NPC stage is preliminary the main influencing factor. Although RIEACC has a low incidence, its malignancy should be highly vigilant.