北京某部7型腺病毒疫情流行病学调查

Epidemiological investigation on an outbreak of type 7 adenovirus in a troop,Beijing city

目的对北京某部7型腺病毒疫情进行流行病学调查,分析其流行因素和传播途径,为制定疫情防控措施提供依据。方法设计流行病学调查表,对某部疫情开展现场调查,描述流行特征;采集患者咽拭子和血清标本,利用普通PCR、荧光定量PCR、ELISA等技术确定病原。结果此次疫情累计发病375例,发病率为24.04%。男、女性发病率分别为27.86%和8.00%(P<0.01);无重症和死亡病例,临床表现为发热(≥37.8℃)(占100.00%),伴有咽痛、咳嗽(占88.68%)、头痛、肌痛(占78.65%)、乏力、呕吐、畏寒、恶心、腹痛和腹泻等症状;实验室检测92份标本,阳性率为73.91%。结论病毒分型鉴定该疫情是由7型腺病毒引起的新兵训练基地呼吸道传染病聚集性疫情。

Objective To conduct an epidemiological investigation and analysis of a type 7adenovirus outbreak in a troop, Beijing city,and analyze the risk factors and transmission routes,so as to provide the evidence for the development of prevention and control measures. Methods The epidemiological questionnaires were designed to conduct the on-the-spot investigations about the outbreak in the troop,and the epidemiological characteristics of the outbreak was described;the throat swabs and serum samples from patients were collected to determine pathogens by using common PCR,real-time PCR,ELISA and other techniques. Results A total of 375cases were included in the outbreak,with the attack rate of 24.04%,and the attack rate in male and female was 27.86%and 8.00%respectively,with statistically significant difference( P <0.01).There was no serious cases and deaths in the outbreak,the clinical manifestations were mainly fever(≥ 37.8℃)(100.00%),accompanied by sore throat,cough(88.68%),headache,myalgia(78.65%),fatigue,vomiting,chills, nausea,abdominal pain and diarrhea.Totally 92samples were tested in the laboratory,and the positive rate was 73.91%. Conclusion The outbreak is a cluster of respiratory infectious diseases caused by adenovirus type 7in the new recruits training base after the identification of virus typing.