Gal-3在肾脏纤维化中的作用研究进展

Research advances of Gal-3 in renal fibrosis

慢性肾脏病(CKD)已成为全球性的公共卫生问题,若进展至终末期肾脏病(ESRD),将给个人、家庭及整个社会带来巨大的负担。CKD的本质是持续刺激的慢性炎症导致肾脏纤维化的发生发展。半乳糖凝集素3(Gal-3)是一个多功能蛋白质,既可调节炎症反应中巨噬细胞的激活,产生转化生长因子(TGF)-β等细胞因子,促进肾脏纤维化的发生,也可调节组织重塑过程中胶原蛋白的表达,促进肾脏纤维化,在炎症及纤维化过程中有不可替代的作用。修饰的柑橘果糖(MCP)和GCS-100均是Gal-3的抑制剂,在一定程度上可缓解肾脏损伤,是潜在的抗肾脏纤维化治疗靶点。然而,Gal-3又被证实具有保护肾脏的作用。在慢性肾脏损伤的早期,Gal-3的抗凋亡作用可保护肾小球及肾小管免受慢性损伤。该文主要对Gal-3在肾脏纤维化中的作用进行综述。

Chronic kidney disease(CKD) has become a global public health problem,deterioration of the disease to endstage renal disease(ESRD) will bring heavy burdens to individuals,families and society.The essence of CKD is occurrence and development of renal fibrosis led by continuous stimulation of chronic inflammation.Galectin-3(Gal-3) is a multifunctional protein, which can not only regulate the activation of macrophages in inflammatory response,produce cytokines such as transforming growth factor(TGF)-β,promote the occurrence of renal fibrosis,but also regulate the expression of collagen in the process of tissue remodeling,promote renal fibrosis,and play an irreplaceable role in inflammation and fibrosis.Both modified citrus fructose(MCP) and GCS-100 are Gal-3 inhibitors,which can alleviate renal injury to a certain extent and are potential targets for anti-renal fibrosis therapy.However,Gal-3 has been shown to have a protective effect on the kidney.In the early stage of chronic renal injury,the antiapoptosis effect of Gal-3 can protect glomeruli and tubules from chronic injury.The present paper mainly reviews the role of Gal 3 in renal fibrosis.