脓毒症相关性脑病诊断及治疗研究进展

Progress in the diagnosis and treatment of sepsis-associated encephalopathy

脓毒症相关性脑病(SAE)是由脓毒症引起的一种弥漫性脑功能障碍,其特征为无中枢神经系统感染,临床上主要表现为与脓毒症有关的精神状态及意识水平改变。SAE早期的临床表现没有特异性,缺乏有效的诊断方法,导致患者住院时间延长、致残率和病死率增高及出院后进一步的认知功能障碍。目前,SAE常用的辅助诊断方法包括意识状态评估、相关的生化检查、神经电生理及影像学检查。该文对SAE的诊断及治疗进展进行综述,以期加深人们对SAE的认识,提高SAE的临床诊断及治疗水平。

Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction caused by sepsis,characterized by no central nervous system infection.The main clinical manifestations are the changes of mental state and consciousness level,which were associated with sepsis.The early clinical manifestations of SAE are not specific and can not be diagnosed in time,resulting in prolonged hospitalization,increased disability rate,higher mortality,and cognitive dysfunction after discharge.Currently, the commonly used auxiliary diagnostic methods of SAE include assessment of the conscious state,biochemical examination, electrophysiological examination and neuroimaging studies.This paper reviews the diagnostic methods and treatments of SAE,so as to deepen the understanding of SAE and improve the level of clinical diagnosis and treatments of SAE.