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溃疡性结肠炎患者血清IL-35水平的变化及与巨噬细胞极化相关因子的关系 被引量:2

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摘要 目的探究溃疡性结肠炎患者血清IL-35水平的变化及与巨噬细胞极化相关因子iNOS和Arg-1的关系。方法选取经内镜明确诊断的溃疡性结肠炎患者39例和同期健康体检者36作为研究对象。酶联免疫吸附实验测定血清IL-35、iNOS和Arg-1的浓度;荧光定量PCR测定外周血单个核细胞中IL-35亚基EBI3及P35 mRNA的相对表达水平。Spearman相关性分析评估血清IL-35及EBI3 mRNA与iNOS和Arg-1及Mayo指数间的关系。结果溃疡性结肠炎患者血清IL-35和iNOS相较对照组均显著下降,而Arg-1则显著上调,差异显著(P<0.05)。此外,溃疡性结肠炎患者EBI3 mRNA表达量显著下降(P<0.05),而P35 mRNA则无显著差异(P>0.05)。相关性分析显示IL-35、EBI3 mRNA与iNOS均呈显著负性相关性,而与Arg-1间呈正相关性;IL-35与Mayo指数呈显著负相关性,而EBI3 mRNA则与Mayo指数间无相关性。结论溃疡性结肠血清IL-35异常下调,并与巨噬细胞极化相关因子成显著相关性。
作者 陈千 薛国辉
出处 《江西医药》 CAS 2019年第9期1118-1120,1133,共4页 Jiangxi Medical Journal
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