拉贝洛尔联合小剂量低分子肝素治疗早发型子痫前期的效果观察

OBSERVATION ON CURATIVE EFFECTS OF LABETALOL COMBINED WITH LOW-DOSE LOW-MOLECULE-WEIGHT HEPARIN ON EARLY-ONSET PREECLAMPSIA

目的:探讨拉贝洛尔联合小剂量低分子肝素治疗早发型子痫前期的临床效果。方法:120例早发型子痫前期患者随机分为治疗组(60例)和对照组(60例),对照组予以常规治疗+拉贝洛尔静脉滴注,治疗组在对照组的基础上予以小剂量低分子肝素皮下注射,两组患者均连续用药7d。比较两组患者治疗前后的血压、24h尿蛋白含量、凝血功能指标、血流动力学指标及妊娠结局。结果:治疗后,治疗组的舒张压、收缩压、24h尿蛋白含量、血液黏度、血细胞比容、不良妊娠结局发生率均显著低于对照组(P<0.05);治疗后,治疗组的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)均显著高于对照组(P<0.05)。结论:拉贝洛尔辅助小剂量低分子肝素治疗早发型子痫前期的效果确切,能够有效改善患者的临床症状、体征及血液循环,从而有助于改善母婴结局。

Objective: To investigate the clinical effects of labetalol combined with low-dose low-molecule-weight heparin(LMWH) on early-onset preeclampsia. Methods: 120 patients with early-onset preeclampsia were randomly divided into treatment group(60 cases) and control group(60 cases). The patients in control group were given routine treatment and labetalol intravenous drip;On this basis, the patients in treatment group were given subcutaneous injection of LMWH;All the patients were treated for 7 d. The blood pressure, 24 h urine protein content, coagulation function indexes, hemodynamics indexes before and after treatment, as well as the pregnancy outcome of the 2 groups were compared. Results: After treatment, the systolic pressure, diastolic pressure, 24 h urine protein content, plasma viscosity, hematocrit and incidence of adverse pregnancy outcomes of patients in treatment group were significantly lower than control group(P<0.05);the prothrombin time and activated partial thromboplastin time were significantly higher(P<0.05). Conclusions: The curative effects of labetalol combined low-dose LMWH on early-onset preeclampsia is effective, which can improve the clinical symptoms, signs and blood circulation effectively;thus it can help to improve maternal and infant outcomes.