丙种球蛋白联合美罗培南治疗新生儿败血症的疗效及对血清IL-6、GM-CSF、PCT水平的影响

Curative Efficacy of Gamma Globulin Combined with Meropenem in the Treatment of Neonatal Sepsis and Its Effects on the Serum IL-6, GM-CSF and PCT Levels

目的:探讨丙种球蛋白联合美罗培南治疗新生儿败血症的疗效及对血清白介素-6 (IL-6)、粒细胞巨噬细胞集落刺激因子(GM-CSF)、降钙素原(PCT)水平的影响。方法:选择2017年1月至2018年12月我院接诊的80例新生败血症患儿作为本研究对象,通过随机数表法将其分为观察组和对照组,每组40例。对照组在常规处理基础上给予美罗培南治疗,观察组在对照组的基础上联合丙种球蛋白治疗。比较两组的临床疗效、症状改善时间、住院时间、治疗前后血清免疫球蛋白G(IgG)、IL-6、GM-CSF、PCT水平的变化及不良反应的发生情况。结果:治疗后7d,观察组临床疗效总有效率显著高于对照组(95%vs. 80%,P<0.05);观察组拒奶改善时间、皮肤颜色及体温正常时间、住院时间均短于对照组(P<0.05);观察组血清Ig G高于对照组,血清IL-6、GM-CSF、PCT均低于对照组(P<0.05)。两组治疗治疗期间均无死亡病例和严重不良反应发生。结论:丙种球蛋白联合美罗培南治疗新生儿败血症的疗效显著优于单用美罗培南治疗,其可有效降低血清IL-6、GM-CSF、PCT的表达,促进患儿恢复。

Objective: To study the curative efficacy of gamma globulin combined with meropenem in the treatment of neonatal sepsis and its effects on the serum interleukin-6(IL-6), granulocyte macrophage colony-stimulating factor(GM-CSF) and procalcitonin(PCT) levels. Methods: 80 patients of neonatal sepsis who were treated from January 2017 to December 2018 in our hospital were selected and divided into the observation group and the control group according to the random number table, with 40 cases in each group.The control group was treated with meropenem on the basis of conventional treatment, while the observation group was combined with gamma globulin on the basis of control group. The clinical efficacy, symptoms improvement time, hospitalization time, changes of the serum immunoglobulin G(IgG), IL-6, GM-CSF, PCT levels before and after treatment and incidence of adverse reactions were compared between the two groups. Results: After 7 days treatment, the total effective rate of observation group was significantly higher than those in the control group.(95% vs. 80%, P<0.05);the refusal improvement time, skin and body temperature normal time, hospitalization time in the observation group were shorter than those in the control group(P<0.05);the serum Ig G in observation group was higher than those in the control group, the serum IL-6, GM-CSF and PCT were lower than those in the control group(P<0.05). There was no deaths and serious adverse reactions during treatment in two groups. Conclusion: The efficacy of gamma globulin combined with meropenem in the treatment of neonatal sepsis was significantly better than meropenem alone, it can effectively reduce the expression of serum IL-6,GM-CSF, PCT levels.