介入栓塞对颅内动脉瘤患者动脉瘤破裂、神经及脑损伤相关因子的影响

Effects of Interventional Embolization on the Related Factors of Aneurysm Rupture, Nerve and Brain Injury in Patients with Intracranial Aneurysms

目的:探讨介入栓塞对颅内动脉瘤患者动脉瘤破裂、神经及脑损伤相关因子的影响。方法:选择我院收治的98例颅内动脉瘤患者,随机分为观察组50例以及对照组48例。观察组应用血管内介入手术,对照组应用显微外科夹闭手术。观察比较两组治疗前后血清胱抑素C(Cys-C)、含半胱氨酸的天冬氨酸蛋白水解酶3(Caspase3)、神经元特异性烯醇化酶(NSE)、星形胶质源性蛋白(S100β)、白介素-6(IL-6)、内皮素-1(ET-1)及基质金属蛋白酶-9(MMP-9)水平的变化。结果:治疗前,两组各项指标水平无显著变化(P>0.05);治疗后,两组血清Cys-C、Caspase3、IL-6、ET-1、MMP-9水平均较治疗前显著降低(P<0.05),且观察组以上指标水平显著低于对照组(P<0.05);而组间及组内前后血清NSE及S100β水平比较差异均无明显统计学意义(P>0.05)。结论:采用介入栓塞治疗颅内动脉瘤患者可能会降低颅内动脉瘤发生破裂的可能性,降低脑损伤程度,且对中枢神经系统影响不大。

Objective: To investigate the effects of interventional embolization on the related factors of aneurysm rupture, nerve and brain injury in patients with intracranial aneurysms. Methods: 98 patients with ntracranial aneurysms in our hospital were randomly divided into 50 cases of the observation group and 48 cases of the control group. The observation group was treated with intravascular interventional operation, while the control group was treated by microsurgical clipping. The expression levels of cystatin C(Cys-C),cysteine containing aspartate proteinase 3(Caspase3), neuron specific enolase(NSE), astrocyte derived protein(S100β), interleukin-6(IL-6), endothelin-1(ET-1) and matrix metalloproteinase-9(MMP-9) of the two groups were observed and compared between two groups. Results: Before treatment, there was no significant change in the levels of indicators in the two groups(P>0.05). After treatment,the levels of Cys-C, Caspase 3, IL-6, ET-1 and MMP-9 in both groups were significantly lower than those before treatment(P<0.05), and the levels of above indexes in the observation group were significantly lower than those in the control group(P<0.05). While there was no significant difference in the serum NSE and S100 beta levels inter group and intra group(P >0.05). Conclusions: Interventional embolization for intracranial aneurysms may reduce the possibility of ruptured intracranial aneurysms, reduce the degree of brain injury,and has little effect on the central nervous system.