腹腔镜手术联合注射用醋酸亮丙瑞林缓释微球治疗子宫内膜异位症的效果观察

Observation on effect of laparoscopic surgery combined with leuprorelin acetate microspheres sustained release for injection in the treatment of endometriosis

目的观察腹腔镜手术联合注射用醋酸亮丙瑞林缓释微球治疗子宫内膜异位症的治疗效果.方法 66例子宫内膜异位症患者,随机分为对照组与实验组,每组33例.对照组采用单纯腹腔镜手术治疗,实验组采用腹腔镜手术联合注射用醋酸亮丙瑞林缓释微球治疗.比较两组患者术后不良反应发生情况、临床治疗效果、术后妊娠情况.结果实验组不良反应发生率9.09%低于对照组的30.30%,差异有统计学意义(P<0.05).观察组患者治疗总有效率96.97%高于对照组的81.82%,差异有统计学意义(P<0.05).实验组妊娠成功率为84.85%(28/33),高于对照组的63.64%(21/33),差异有统计学意义(P<0.05).结论子宫内膜异位症患者给予腹腔镜手术联合注射用醋酸亮丙瑞林缓释微球治疗效果显著,值得临床推广应用.

Objective To observe the therapeutic effect of laparoscopic surgery combined with leuprorelin acetate microspheres sustained release for injection in the treatment of endometriosis. Methods A total of 66 endometriosis patients were randomly divided into control group and experimental group, with 33 cases in each group. The control group was treated with laparoscopic surgery only, and the experimental group was treated with laparoscopic surgery combined with leuprorelin acetate microspheres sustained release for injection. Comparison was made on occurrence of postoperative adverse reactions, clinical therapeutic effect and postoperative pregnancy status between the two groups. Results The experimental group had lower incidence of adverse reactions as 9.09% than 30.30% in the control group, and the difference was statistically significant(P<0.05). The observation group had higher total treatment effective rate as 96.97% than 81.82% in the control group, and the difference was statistically significant(P<0.05). The experimental group had higher success rate of pregnancy as 84.85%(28/33) 63.64%(21/33) in the control group, and the difference was statistically significant(P<0.05). Conclusion Laparoscopic surgery combined with leuprorelin acetate microspheres sustained release for injection shows significant therapeutic effect in the treatment of patients with endometriosis, and it is worthy of clinical promotion and application.