替加环素相关不良反应分析

Analysis of Tigecycline-Associated Adverse Reaction

近年,随着临床多重耐药菌的问题越来越严峻,替加环素的使用越来越受到临床医生的重视。替加环素因独特的抗菌机制,使其对革兰阳性、革兰阴性需氧菌,厌氧菌,特别是泛耐药致病菌均具有非常高的活性,临床主要用于治疗成年患者复杂皮肤、软组织感染、复杂腹腔内感染,社区获得性肺炎,以及泛耐药鲍曼不动杆菌所致的院内获得性肺炎。替加环素的常见不良反应为腹泻、恶心、呕吐等胃肠道反应,一般可耐受,但其严重不良反应,使其最大抗菌效应得不到很好的发挥,限制了重症患者的进一步救治,文章通过分析替加环素各种不良反应,希望可以减少临床不良事件的发生。

In recent years, the problem about multiple drugresistant bacteria has been more and more serious, so tigecycline were being used more and more frequently. Because of the unique antibacterial mechanism, tigecycline has a very high activity in gram-positive and gram-negative aerobic bacteria, anaerobic bacteria, especially extensive drug-resistant pathogens. It mainly used in the treatment of adult patients with complicated skin and soft tissue infections, complicated intra-abdominal infections, communityacquired pneumonia, and nosocomial acquired pneumonia caused by acinetobacter baumannii. The common adverse reactions of tigecycline are gastrointestinal reactions such as diarrhea, nausea and vomiting, which are generally tolerable. Due to the severe adverse reactions, not only its maximum effect but also the further treatment of critically ill patients is limited. The aim of this article is to analyze all kinds of adverse reactions about tigecycline, hoping it can reduce the occurrence of clinical adverse events.