某院碳青霉烯类抗菌药物临床用药的相关因素分析

Analysis on Related Factors of Clinical Medication of Antimicrobial Agents of Carbapenems in a Hospital

目的:分析碳青霉烯类抗菌药物临床用药的相关因素,为临床合理使用提供参考。方法:抽取2019年1-3月期间采用碳青霉烯类抗菌药物治疗的住院患者98例临床资料,分析资料中患者的基本情况、科室分布、用药频度、药物利用指数和病原学检查结果,点评住院患者用药的合理性。结果:98例患者中,注射用亚胺培南西-司他汀钠、注射用比阿培南用药频度(DDDs)分别为212.25和187.50;药物利用指数(DUI)分别为0.63和0.57;使用碳青霉烯类抗菌药物最多的临床科室为呼吸科(40.82%)和ICU(25.51%);总微生物送检率为91.84%,其中亚胺培南-西司他汀钠按药敏结果选药35例(63.64%),比阿培南按药敏结果选药28例(54.90%)。结论:碳青霉烯类抗菌药物在使用中应加强干预管理,为临床合理用药和制定精细化管理措施提供参考。

Objective: To analyze the related factors of clinical medication of antimicrobial agents of carbapenems and to provide a reference for clinical rational use. Methods: Clinical data of 98 in-patients treated with carbapenems from January to March 2019 were extracted. The basic situation, department distribution, defined daily dose system(DDDs), drug utilization index(DUI) and pathogenic examination results of the patients in the data were analyzed, and the rationality of medication was commented. Results: Among the 98 patients, the DDDs of imipenenci-statins for injection and biapenem for injection were 212.25 and 187.50, and the DUI were 0.63 and 0.57, respectively. The clinical departments using carbapenems most were respiratory department(40.82%) and intensive care unit(ICU)(25.51%). The total microbial testing rate was 91.84%, in which 35 cases(63.64%) were selected based on drug sensitivity results, and28 cases(54.90%) were selected based on drug sensitivity results. Conclusion: The intervention management of carbapenems should be strengthened in the use of antibiotics to provide a reference for rational drug use in clinical practice and the formulation of fine management measures.