病毒样颗粒疫苗的免疫机制研究及应用进展

Research progress in immune mechanism and application of virus-like particle vaccines

病毒样颗粒(virus-like particle,VLP)因具有良好的免疫原性以及较高的安全性,逐渐成为当今药物及疫苗研究的热点.鉴于VLP具有高度重复表面结构的特性,其可通过多种途径引起有效的体液和细胞免疫应答.目前可用多种表达系统表达VLP,且随着对VLP研究的深入,已有多种VLP疫苗进入临床试验阶段,部分VLP疫苗已经商业化.此文对VLP免疫机制及VLP疫苗研究进展做一综述.

Virus-like particle (VLP) has gradually become a hot spot in drug and vaccine research due to its good immunogenicity and high safety. In view of the highly repetitive surface structure of VLP, it can induce effective humoral and cellular immune responses through many pathways.At present, VLP can be expressed by a variety of expression systems. With the development of researches on VLP, many VLP vaccines have entered clinical trials and some VLP vaccines have been commercialized. This review focuses on the the immune mechanism of VLP and the progress of research on VLP vaccines.