摘要
目的建立牛黄清胃丸中掺伪品山麦冬的测定方法,以了解该制剂中麦冬掺伪情况。方法采用液相色谱-串联电喷雾三重四级杆质谱(HPLC-MS-MS)法,多反应监测模式(MRM)对牛黄清胃丸中的山麦冬皂苷B和短葶山麦冬皂苷C进行分析。结果18个批次牛黄清胃丸中15个批次均可检出山麦冬特征成分山麦冬皂苷B或短葶山麦冬皂苷C,含量为0.10~1.19μg·g^-1。结论制剂中存在麦冬和山麦冬的混用情况。
OBJECTIVE To establish the detection method of Liriopes Radix in Niuhuang Qingwei pills to uncover the adulteration situation of Ophiopogonis Radix in Niuhuang Qingwei pills.METHODS Liriopesides B and liriope muscari baily saponins C in Niuhuang Qingwei pills were analyzed by HPLC-MS-MS in MRM mode.RESULTS In the 18 batches of Niuhuang Qingwei pills,liriopesides B and liriope muscari baily saponins C,the index compounds of Liriopes Radix,were detected in 15 batches of samples in the concentrations of 0.10 - 1.19 μg·g^- 1.CONCLUSION The adulteration of Ophiopogonis Radix with Liriopes Radix should be paid more attention to.
作者
王峰
何轶
于健东
戴忠
马双成
WANG Feng;HE Yi;YU Jian-dong;DAI Zhong;MA Shuang-cheng(Naitional Instituts for Food and Drug Control,Beijing 100050,China)
出处
《中国药学杂志》
CAS
CSCD
北大核心
2019年第16期1332-1335,共4页
Chinese Pharmaceutical Journal
关键词
牛黄清胃丸
麦冬
山麦冬
液质联用
Niuhuang Qingwei pills
Ophiopogonis Radix
Liriopes Radix
HPLC-MS /MS