健康成年人血清血管内皮生长因子生物学参考区间的确立

Establishment of biological reference interval of serum vascular endothelial growth factor of healthy adults

目的 探讨健康成年人血清中血管内皮生长因子的生物学参考区间.方法 收集2018年11-12月在该院体检的健康成年人为研究对象,收集其血清标本.采用双抗体夹心法进行血管内皮生长因子水平的测定,根据不同性别、不同年龄进行分组,比较不同组间血管内皮生长因子水平,并利用SPSS统计学软件进行统计学分析.结果 血管内皮生长因子水平在不同性别之间差异有统计学意义(P<0.05),不同年龄组之间差异无统计学意义(P>0.05).男性血管内皮生长因子水平参考区间为18.36~158.60 pg/m L,女性参考区间为16.11~121.46 pg/m L.结论 根据不同性别建立了该实验室血清中血管内皮生长因子的生物学参考区间,为临床的相关疾病诊断提供了参考标准.

Objective To establish the biological reference interval of vascular endothelial growth factor (VEGF) in healthy adults. Methods A total of198 healthy adults from November to December2018 in the hospital were collected.The serum samples were selected,and the levels of VEGF were measured and analyzed by double-antibody sandwich method. Results VEGF of male was significantly different with that of female ( P<0.05),but there were no significant difference in different age groups ( P>0.05).The reference value of male was18.36-158.60 pg/mL,and which of the female was16.11-121.46 pg/mL. Conclusion Biological reference intervals of VEGF in different genders have been established,which could provide the basis reference indicators for the diagnosis of disease.