磁共振T2 mapping成像评价膝关节骨关节炎软骨损伤的应用价值

Application value of magnetic resonance T2 mapping imaging in evaluation of knee osteoarthritis cartilage injury

目的观察软骨损伤中T2值的变化规律及T2 mapping成像对膝关节骨关节炎(osteoarthritis,OA)软骨损伤的诊断价值和临床意义。材料与方法选取60例膝关节OA患者为观察组及30例健康志愿者为对照组,两组受试者行膝关节MRI常规和T2 mapping序列扫描。分别测量两组受试者股骨内、外侧髁负重区与非负重区,胫骨内、外侧平台及髌软骨平均T2值。结果观察组各区域软骨平均T2值均显著高于对照组(P<0.05);除对照组股骨内侧髁外,观察组股骨内外侧髁和对照组股骨外侧髁负重区平均T2值均显著高于非负重区(P<0.05);除观察组股骨内侧髁负重区外,两组各区域浅层软骨平均T2值均显著高于同区域深层软骨(P<0.05);重度和轻度OA组股骨内外侧髁负重区平均T2值均显著高于正常组(P<0.05),重度OA组和轻度OA组股骨内外侧髁负重区平均T2值无显著差异(P>0.05)。结论 T2 mapping可测量出软骨T2值的改变,有助于OA患者及时开始治疗,监测疾病进展以及对软骨修复进行随访,在评估软骨变化方面有重要的应用价值和临床意义。

Objective: To observe the change of T2 value in cartilage injury and the diagnostic value and clinical significance of T2 mapping imaging in osteoarthritis (OA) cartilage injury. Materials and Methods: Sixty patients with knee osteoarthritis were selected as the observation group and thirty healthy volunteers were selected as the control group. The two group patients underwent GE Signa 3.0 T MRI scanning including conventional and T2 mapping imaging sequence. The average T2 value of cartilage in 7 regions including weight-bearing area and nonweight- bearing area of medial and lateral femoral condyle, medial tibial plateau, lateral tibial plateau and patella cartilage were measured respectively. Results: The average T2 values of cartilage in regions in the observation group were higher compared with the control group (P<0.05). Except for the medial femoral condyle of the control group, the average T2 values of the weight-bearing areas of medial and lateral femoral condyle of the observation group and lateral femoral condyle of the control group were higher than those of the corresponding non-weight-bearing areas (P<0.05). The average T2 value of superficial cartilage was higher than that of deep cartilage in the same region except for the weight-bearing area of medial femoral condyle in the observation group (P<0.05). The average T2 values of the weightbearing areas of medial and lateral femoral condyle in the severe and mild OA group were both higher compared with the normal group (P<0.05), however, there was no significant difference in the T2 value of weight-bearing areas of medial and lateral femoral condyle between the severe OA group and the mild OA group (P>0.05). Conclusions: T2 mapping can detect the changes of cartilage T2 value and it is helpful for OA patients to start treatment without delay, monitor disease progress and conduct the follow-up of cartilage repair.