联合检测CRP和PCT在鉴别小儿支气管肺炎病原体中的价值

Combined Detection of CRP and PCT in the Identification of Pathogens in Children with Bronchopneumonia

目的探讨C-反应蛋白(C-reactive protein,CRP)及降钙素原(PCT)的联合检测在鉴别小儿支气管肺炎病原体中的临床应用价值。方法随机选择2017年10月-2018年10月已确诊的支气管肺炎患儿90例,根据感染的不同病原体类型分为细菌性感染组32例,病毒性感染组29例,支原体感染组29例,并选取同期进行健康体检的30例儿童作为对照组,对所有研究对象的CRP、PCT水平进行检测,将实验结果进行对比分析。结果与对照组CRP:(0.69±0.21)mg/L和PCT:(0.24±0.1)ng/L相比,细菌性感染组的CRP(25.14±24.91)mg/L和PCT(0.71±0.78)ng/L水平均明显升高,差异有统计学意义(P<0.05);与对照组CRP:(0.69±0.21)mg/L和PCT:(0.24±0.1)ng/L相比,支原体感染组的CRP(4.29±4)mg/L水平明显升高,差异有统计学意义(P<0.05),PCT(0.23±0.31)ng/L水平和差异无统计学意义(P>0.05);与对照组CRP(0.69±0.21)mg/L和PCT(0.24±0.1)ng/L相比,病毒性感染组的CRP (1.53±1.88)mg/L和PCT (0.20±0.28)ng/L水平均差异无统计学意义(P>0.05)。细菌性感染组的CRP和PCT的联合检测阳性率均高于病毒性感染组和支原体感染组,差异有统计学意义(P<0.05)。结论联合检测CRP和PCT可用于小儿支气管肺炎早期的病原体鉴别诊断,对指导临床用药、患儿预后有积极的临床意义。

Objective To investigate the clinical value of combined detection of C-reactive protein (CRP) and procalcitonin (PCT) in the identification of pathogens in children with bronchial pneumonia.Methods 90 children with bronchial pneumonia who were diagnosed between October 2017 and October 2018 were randomly selected.According to the different pathogen types,there were 32 cases of bacterial infection,29 cases of viral infection,and 29 cases of mycoplasma infection.And 30 children who were selected for health examination at the same time as the control group,the CRP and PCT levels of all subjects were tested,and the experimental results were compared and analyzed.Results CRP (25.14±24.91)mg/L and PCT (0.71±0.78)ng/L in the bacterial infection group compared with the control group CRP:(0.69±0.21)mg/Land PCT:(0.24 ± 0.1)ng/L,and the level was significantly increased,and the difference was statistically significant (P<0.05.Compared with the control group CRP:(0.69±0.21)mg/L and PCT:(0.24±0.1)ng/L,the CRP of the mycoplasma-infected group of the level of (4.29±4.00)mg/L was significantly increased,the difference was statistically significant (P<0.05),and the level of PCT (0.23±0.31)ng/L was not statistically significant different (P>0.05).Compared with the control group CRP:(0.69±0.21)mg/LandPCT:(0.24±0.1)ng/L.There was no significant difference in CRP (1.53±1.88)mg/L and PCT (0.20±0.28)ng/L between the viral infection group (P>0.05).The positive rate of combined detection of CRP and PCT in the bacterial infection group was higher than that in the viral infection group and the mycoplasma infection group,and the difference was statistically significant (P<0.05).Conclusion Combined detection of CRP and PCT can be used for the differential diagnosis of pathogens in children with early bronchopneumonia.It has positive clinical significance for guiding clinical medication and prognosis of children.