人乳头状瘤病毒(HPV)分型与尖锐湿疣(CA)患者术后复发的关系研究

Relationship between Human Papillomavirus(HPV) Typing and Postoperative Recurrence in Patients with Condyloma Acuminatum(CA)

目的探究人乳头状瘤病毒基因分型与尖锐湿疣患者术后复发之间的关系,讨论其临床研究价值。方法方便择取该院在2016年4月-2018年6月间所收治的75例尖锐湿疣患者作为该次研究对象,并根据患者的分型结果将其分为高危组(n=25)、混合组(n=25)以及低危组(n=25),所有患者均应用核酸分子快速导流杂交基因芯片技术进行人乳头状瘤病毒基因分型,所有确诊患者均应用微波治疗后卡介菌多糖核酸注射液肌肉注射治疗,并对患者进行为期6个月的随访,评价3组患者的复发率。结果治疗完成后,高危型组中有11例患者发生复发,复发率为44.00%,而混合型组中有6例患者发生复发,复发率为24.00%,低危型组中有2例患者发生复发,复发率为8.00%,其复发率高低与感染的HPV型别关系密切,数据对比差异有统计学意义(P<0.05)。结论高危型组患者的复发率要显著高于混合型组患者复发率;混合型组患者的复发率要显著高于低危型组患者复发率。

Objective To investigate the relationship between human papillomavirus genotyping and postoperative recurrence in patients with condyloma acuminatum,and to discuss its clinical research value.Methods Seventy-five patients with condyloma acuminata admitted to our hospital from April 2016 to June 2018 were convenient enrolled in this study.They were divided into high-risk group (n=25) and mixed group (n=25) and low-risk group (n=25),according to the patient's classification results.All patients were subjected to genotyping of human papillomavirus using nucleic acid molecule rapid flow-through hybridization microarray technology.All confirmed patients were treated with microwave therapy.Polysaccharide nucleic acid injection was intramuscularly injected,and patients were followed up for 6 months.Evaluate the recurrence rate of the three groups.Results After the completion of treatment,11 patients in the high-risk group had recurrence,the recurrence rate was 44.00%,and 6 patients in the mixed group had recurrence,the recurrence rate was 24.00%,and 2 patient in the low-risk group occurred.The recurrence rate was 8.00%.The recurrence rate was closely related to the HPV type of infection,and the data were statistically significant different (P<0.05).Conclusion The recurrence rate of patients in high-risk group is significantly higher than that in patients with mixed-risk group.The recurrence rate of patients in mixed group is significantly higher than that in low-risk group.