桃红四物汤联合伤科接骨片治疗胫腓骨骨折临床研究

Clinical Study of Taohong Siwu Tang Combined with Shangke Jiegu Tablets for Fracture of Tibia and Fibula

目的:探讨桃红四物汤联合伤科接骨片对胫腓骨骨折患者骨痂生长情况、骨折部位疼痛和消肿时间的影响及其机制。方法:将收治的93例胫腓骨骨折患者按照随机数字表法随机分为甲乙丙3组,其中甲组给予钙尔奇D片进行口服治疗,乙组则给予伤科接骨片进行口服治疗,丙组给予桃红四物汤联合伤科接骨片进行治疗。观察各组不同时点的骨痂生成情况以及疼痛程度和消肿时间等指标,分析各组患者的成纤维细胞生长因子b(bFGF)和血骨形态发生蛋白2(BMP-2)的含量。结果:经过4周、6周和8周治疗后,乙组和丙组骨痂生长评分均优于甲组(P<0.05)。其中4周和6周治疗后,丙组骨痂生长评分优于同时点乙组(P<0.05)。经过8周治疗后乙组和丙组间的骨痂生长评分比较,差异无统计学意义(P>0.05)。用药3天后、5天后、7天后和9天后,乙组和丙组疼痛评分低于甲组(P<0.05);用药5天后和7天后,丙组疼痛评分低于乙组(P<0.05)。乙组和丙组消肿时间低于甲组,且丙组消肿时间低于乙组(P<0.05)。经过用药2周后,乙组和丙组bFGF和BMP-2含量均优于甲组(P<0.05),丙组BMP-2含量优于乙组(P<0.05)。结论:对于胫腓骨骨折患者采用桃红四物汤联合伤科接骨片进行治疗能够有效促进其骨痂生长,缩短患者消肿时间和减轻疼痛症状,对患者的骨骼生长具有较好的促进作用。

Objective: To discuss the effect of Taohong Siwu tang combined with Shangke Jiegu tablets on callus growth,pain in the fracture site and the time of detumescence in patients with fracture of tibia and fibula, and its functional mechanism.Methods : Divided 93 cases of patients with fracture of tibia and fibula who were hospitalized and treated in our hospital into the group A, the group B and the group C randomly. The group A received the oral administration of Caltrate vitamin D tablets, the group B received the oral administration of Taohong Siwu tang, while the group C received Taohong Siwu tang combined with Shangke Jiegu tablets. Observed such indexes as callus growth, degree of pain and time of detumescence in each group at different time points,and analyzed the contents of basic fibroblast growth factor(bFGF) and bone morphogenetic protein2(BMP-2) of patients in each group. Results : After treatment for 4 weeks, 6 weeks and 8 weeks, the scores of callus growth in the group B and the group C were better than those in the group A( P < 0.05). After treatment for 4 weeks and 6 weeks,the scores of callus growth in the group C were better than those in the group B at the same time point( P < 0.05). After treatment for 8 weeks, comparing the scores of callus growth in-between the group B and the group C, there was no significant difference being found(P > 0.05). After medication for 3 days, 5 days and 7 days, the score of pain in the group B and the group C was lower than that in the group A( P < 0.05);after medication for 5 days and 7 days, the score of pain in the group C was lower than that in the group B( P < 0.05). The time of detumescence in the group B and the group C was shorter than that in the group A, and the time of detumescence in the group C was shorter than that in the group B( P <0.05). After medication for 2 weeks, the contents of bFGF and BMP-2 in the group B and the group C better than those in the group A(P < 0.05), and the content of BMP-2 in the group C was better than those in the group B( P < 0.05).Conclusion : The application of Taohong Siwu tang combined with Shangke Jiegu tablets for patients with fracture of tibia and fibula can effectively promote callus growth, shorten the time of detumescence and alleviate pain symptoms, which has relatively good effect in promoting bone growth of patients.