加味参芪地黄汤联合常规西药治疗气阴两虚型慢性肾小球肾炎临床研究

Clinical Study on Modified Shenqi Dihuang Tang Combined with Routine Western Medicine for Chronic Glomerulonephritis with Deficiency of Both Qi and Yin

目的:观察加味参芪地黄汤联合常规西药治疗气阴两虚型慢性肾小球肾炎的临床疗效。方法:选取130例气阴两虚型慢性肾小球肾炎患者,按随机数字表法分为观察组和对照组各65例。对照组给予常规西药治疗,观察组在此基础上服用加味参芪地黄汤。对比2组临床疗效,观察患者治疗前后肾功能指标及炎症因子水平的变化。结果:总有效率观察组84.62%,对照组72.31%,2组比较,差异有统计学意义(P <0.05)。治疗后,2组尿素氮(BUN)、血肌酐(SCr)、尿蛋白水平均较治疗前降低,肾小球滤过率(GFR)均较治疗前升高,差异均有统计学意义(P <0.05);观察组BUN、SCr、尿蛋白水平比对照组下降更明显,GFR比对照组升高更明显,差异均有统计学意义(P <0.05)。治疗后,2组红细胞沉降率(ESR)、超敏C反应蛋白(hs-CRP)水平均较治疗前降低(P <0.05),观察组ESR、hs-CRP水平均比对照组下降更明显(P <0.05)。结论:在常规西医治疗基础上加服参芪地黄汤加味治疗气阴两虚型慢性肾小球肾炎有良好的疗效,可改善患者的肾功能,降低炎症因子水平。

Objective:To observe the clinical effect of modified Shenqi Dihuang tang combined with routine western medicine for chronic glomerulonephritis with deficiency of both qi and yin. Methods:Selected 130 cases of patients with chronic glomerulonephritis with deficiency of both qi and yin, and divided them into the observation group and the control group randomly, 65 cases in each group. The control group received routine western medicine,while the observation group additionally received the oral administration of modified Shenqi Dihuang tang. Compared the clinical effect in both groups,observed the changes in indexes of renal function and levels of inflammatory factors of patients before and after treatment. Results:The total effective rate was 84.62% in the observation group and72.31% in the control group,difference being significant(P<0.05). After treatment, the levels of blood urea nitrogen(BUN), serum creatinine(SCr) and urinary protein in both groups were lower than those before treatment,and the glomerular filtration rate(GFR) was higher than that before treatment, differences being significant(P < 0.05);the levels of BUN, SCr and urinary protein in the observation group were decreased more significantly than those in the control group,and GFR was increased more significantly than that in the control group, differences being significant(P < 0.05). After treatment, the levels erythrocyte sedimentation rate(ESR) and hypersensitive C-reactive protein(hs-CRP) in both groups were lower than those before treatment(P < 0.05),and the levels of ESR and hs-CRP in the observation group were decreased more significantly than those in the control group(P < 0.05). Conclusion: The additional application of modified Shenqi Dihuang tang based on routine western medicine has good therapeutic effect in treating chronic glomerulonephritis with deficiency of both qi and yin, which can improve the renal function of patients and decrease the levels of inflammatory factors.