解毒化斑汤联合复方甘草酸苷注射液治疗儿童过敏性紫癜疗效观察及对免疫指标的影响

Observation of Jiedu Huaban Tang Combined with Compound Glycyrrhizin Injection for Henoch-Schonlein Purpura in Children and Its Effect on Immune Indexes

目的:探讨解毒化斑汤联合复方甘草酸苷注射液治疗儿童过敏性紫癜血热妄行证的疗效及对免疫功能的影响。方法:将收治的102例过敏性紫癜患儿,按随机数字表法分为观察组和对照组,每组51例。2组患儿均给予对症治疗。对照组采取复方甘草酸苷注射液治疗,观察组在对照组基础上采取解毒化斑汤治疗。2组患儿连续治疗2周。比较2组患儿皮肤紫癜、消化道病变、关节肿痛及肾脏病变消除时间、皮肤紫癜改善评分及临床疗效,检测2组患儿血清IL-4、IL-6及IFN-γ水平,监测2组患儿治疗过程中不良反应情况。结果:治疗后,观察组患儿皮肤紫癜、消化道病变、关节肿痛及肾脏病变消除时间低于对照组,2组比较,差异有统计学意义(P<0.01)。治疗后,2组患儿皮肤紫癜改善评分降低,与治疗前比较,差异有统计学意义(P<0.01)。治疗后1周和2周,观察组患儿皮肤紫癜改善评分低于对照组同期,差异有统计学意义(P<0.01)。观察组总有效率为98.04%,高于对照组(82.36%),差异有统计学意义(P<0.05)。治疗后,2组患儿血清IL-4、IL-6及IFN-γ水平明显下降,与治疗前比较,差异有统计学意义(P<0.01)。观察组治疗后血清IL-4、IL-6及IFN-γ水平低于对照组,差异有统计学意义(P<0.01)。结论:解毒化斑汤联合复方甘草酸苷注射液治疗儿童过敏性紫癜血热妄行证有效安全,调节患儿IL-4、IL-6以及IFN-γ水平可能是其疗效途径之一。

Objective : To discuss the curative effect of Jiedu Huaban tang combined with compound glycyrrhizin injection on henoch-schonlein purpura with frenetic movement of blood due to heat syndrome in children, and its effect on immune function. Methods : A total of 102 cases of children with henoch-schonlein purpura in our hospital were divided into the observation group and the control group according to the random number table method, 51 cases in each group. Both groups were given symptomatic treatments. The control group was treated with compound glycyrrhizin injection, and the observation group was additionally treated with Jiedu Huaban tang based on the treatment of the control group. Both groups were treated for two weeks. The elimination time of the purpura, the gastrointestinal lesions, the swelling and pain of joints and the kidney lesions, the scores of improvement of purpura and the clinical effect in the two groups were compared. The levels of IL-4, IL-6 and IFN-γ in serum in the two groups were detected. During the treatment, the adverse reactions in the two groups were monitored. Results : After treatment, the elimination time of purpura, gastrointestinal lesions, swelling and pain of joints and kidney lesions in the observation group was shorter than that in the control group, the difference being significant( P < 0. 01). After treatment, the scores of improvement of purpura in the two groups were decreased when compared with those before treatment, the difference being significant( P < 0. 01). One week and two weeks after treatment,the scores of improvement of purpura in the observation group were lower than those in the control group at the same period, the difference being significant( P < 0. 01). The total effective rate was 98. 04 % in the observation group, higher than that of 82. 36 % in the control group, the difference being significant( P < 0. 05). After treatment, the levels of IL-4,IL-6 and IFN-γ in serum in the two groups were significantly decreased when compared with those before treatment, the difference being significant( P < 0. 01), and the above levels in the observation group were lower than those in the control group, the difference being significant( P < 0. 01). Conclusion : The therapy of Jiedu Huaban tang combined with compound glycyrrhizin injection in treating henoch-schonlein purpura with frenetic movement of blood due to heat syndrome in children is effective and safe. The regulation of levels of IL-4, IL-6 and IFN-γ in children may be one of its effective ways.