毛细支气管炎患儿呼出气一氧化氮检测应用价值

The clinical value of fractional exhaled nitric oxide in children with bronchiolitis

目的探讨毛细支气管炎患儿呼出气一氧化氮(FeNO)检测的意义及应用价值。方法以2018年1至9月收治的49例初发毛细支气管炎住院患儿为研究对象,根据呼吸道合胞病毒(RSV)检测结果分为RSV组(27例)和非RSV组(22例);另选取同期同年龄健康体检儿童17例作为健康对照组。对各组进行潮气呼吸法呼出气一氧化氮检测,RSV组和非RSV组患儿在缓解期(1~2周)和恢复期(4~6周)再次检测,比较检测结果。结果 RSV组、非RSV组以及健康对照组间性别、年龄差异无统计学意义(P>0.05)。RSV组及非RSV组FeNO水平在急性期、缓解期和恢复期间的差异均有统计学意义(P<0.05)。在恢复期,FeNO水平在RSV组、非RSV组和健康对照组间的差异有统计学意义(P<0.05),以RSV组FeNO水平最高。在急性期和缓解期,FeNO水平在三组间的差异无统计学意义(P>0.05)。结论毛细支气管炎(包括RSV感染和非RSV感染)患儿在急性期和缓解期的FeNO水平与健康同龄儿童无差异,在恢复期高于健康同龄儿童。

Objective To explore the significance and application value of fractional exhaled nitric oxide (FeNO) in children with bronchiolitis. Methods A total of 49 hospitalized children with primary bronchiolitis admitted from January to September 2018 were selected as study subjects. According to the respiratory syncytial virus (RSV) test results, they were divided into RSV group (27 cases) and non-RSV group (22 cases). In addition, 17 healthy children of the same age were selected as the healthy controls. Nitric oxide in exhaled breath was detected by tidal breathing method in each group. Children in RSV group and non-RSV group were tested again in the remission period (1-2 weeks) and the recovery period (4-6 weeks), and the results were compared. Results There was no difference in sex and age among RSV group, non-RSV group and control group (P>0.05). The FeNO levels in both RSV group and non-RSV group were statistically significantly different among the acute, remission and recovery phases (P<0.05). During the recovery period, there was significant difference in the FeNO levels among RSV group, non-RSV group and healthy control group (P<0.05), with RSV group having the highest FeNO levels. There was no difference in the FeNO levels among the three groups in either acute phase or remission phase (P>0.05). Conclusions The FeNO levels in children with bronchiolitis having or not having RSV infection in both acute and remission phases were not different from those of healthy children at the same age, and were higher during the recovery phase than those of healthy children at the same age.