白细胞介素-6和前白蛋白与左心室射血分数保留心力衰竭的相关性

Correlation of interleukin-6 and prealbumin with heart failure with preserved ejection fraction

目的探讨白细胞介素-6(IL-6)和前白蛋白(PA)与左心室射血分数保留心力衰竭(HF-PEF)的相关性。方法回顾性分析2017年6月至2019年5月中国医科大学附属第一医院老年心血管内科HF-PEF患者126例,根据彩色多普勒超声心动图结果将患者分为左心室舒张功能减低组和左心室舒张功能正常组,每组63例,比较2组患者的IL-6、PA和脑钠肽(BNP)等生化指标水平。多因素logistic回归分析HF-PEF的影响因素。采用SPSS22.0统计软件对数据进行分析。结果左心室舒张功能减低组相比左心室舒张功能正常组年龄[(78.2±9.3)和(70.3±8.9)岁]、体质量指数[(25.2±3.4)和(23.8±2.8)kg/m^2]、BNP[(115.0±128.9)和(46.7±59.5)pg/ml]、E/e′[(13.4±5.5)和(9.2±1.8)]、IL-6[(5.3±5.2)和(3.3±3.4)pg/ml]水平高,白蛋白[(38.9±3.8)和(40.7±3.8)g/L]、PA[(21.5±4.6)和(24.7±5.2)mg/dl]水平低,差异均有统计学意义(P<0.05)。Logistic回归分析结果表明年龄(OR=1.062,95%CI1.007~1.119;P=0.026)及E/e′(OR=1.365,95%CI1.127~1.653;P=0.002)与HF-PEF正相关,PA与HF-PEF负相关(OR=0.916,95%CI0.842~0.997;P=0.043)。结论HF-PEF与年龄及PA水平相关,检测PA可能有助于HF-PEF的早期诊断。

Objective To investigate the correlation of interleukin-6 (IL-6) and prealbumin (PA) with heart failure with preserved ejection fraction (HF-PEF).Methods A total of 126 HF-PEF patients admitted in our department from June 2017 to May 2019 were recruited,and their clinical data were collected and retrospectively analyzed.According to the results of echocardiography,the patients were divided into decreased left ventricular diastolic function group and normal left ventricular diastolic function group,with 63 patients in each group.The levels of IL-6,PA,brain natriuretic peptide (BNP) and other biochemical indicators were compared between the 2 groups.Multivariate logistic regression analysis was used to identify the influencing factors of HF-PEF.SPSS statistics 22.0 was used for data analysis.Results The decreased left ventricular diastolic function group had significantly older age [( 78.2±9.3 ) vs (70.3±8.9)years],higher body mass index [(25.2±3.4) vs (23.8±2.8)kg/m^2],increased E/e′[(13.4±5.5) vs (9.2±1.8)] and elevated levels of BNP [(115.0±128.9) vs (46.7±59.5)pg/ml] and IL-6 [(5.3±5.2) vs (3.3±3.4)pg/ml],but obviously lower levels of albumin [(38.9±3.8) vs (40.7±3.8)g/L] and PA [(21.5±4.6) vs (24.7±5.2)mg/dl] when compared with the normal left ventricular diastolic function group ( P <0.05).Logistic regression analysis showed that age ( OR =1.062,95% CI 1.007-1.119;P =0.026) and E/e′( OR =1.365,95% CI 1.127-1.653;P =0.002) were positively correlated with HF-PEF,while PA was negatively correlated with HF-PEF ( OR =0.916,95% CI 0.842-0.997;P =0.043).Conclusion HF-PEF is related to age and PA level.Detection of PA may be helpful to early diagnosis of HF-PEF.