利培酮与氯氮平治疗精神分裂症的效果对比

Effect comparison of Risperidone and Clozapine in the treatment of schizophrenia

目的比较利培酮与氯氮平治疗精神分裂症的临床效果。方法选取2017年8月~2018年11月我院收治的106例精神分裂症患者作为研究对象,按照随机数字表法分为对照组与观察组,每组各53例。对照组患者给予氯氮平治疗,观察组给予利培酮治疗。比较两组患者各项血糖指标、病情及生活质量的改善情况。结果两组患者治疗后的空腹血糖(FBG)和餐后3h血糖(3hPBG)明显高于治疗前(P<0.05),对照组患者餐后1h血糖(1hPBG)明显高于治疗前,观察组患者1hPBG明显低于治疗前,差异均有统计学意义(P<0.05);观察组患者治疗后的FBG、1hPBG和3hPBG水平均低于对照组,差异有统计学意义(P<0.05);两组患者治疗后的阳性症状评分、简易精神病理评分均低于治疗前,阴性症状评分高于治疗前,差异有统计学意义(P<0.05);两组患者治疗前与治疗后的阳性症状、阴性症状及简易精神病理评分比较,差异均无统计学意义(P>0.05);两组患者治疗后的生理、心理、社会环境和精神方面的生活质量评分均明显高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。结论在精神分裂症患者的治疗过程中,采用利培酮与氯氮平均有显著的治疗效果。但相较氯氮平,采用利培酮对患者的血糖水平影响更小,且对患者的生活质量提升更高,值得临床推广实施。

Objective To compare the clinical effect of Risperidone and Clozapine in the treatment of schizophrenia. Methods A total of 106 patients with schizophrenia admitted to our hospital from August 2017 to November 2018 were selected as the study subjects. According to the random number table method, they were divided into control group and observation group, with 53 cases in each group. The control group was treated with Clozapine, and the observation group was treated with Risperidone. The improvement situation of blood sugar index, condition and quality of life in the two groups were compared. Results After treatment, fasting blood glucose (FBG) and 3-hour postprandial blood glucose (3 h PBG) in the two groups were significantly higher than before treatment(P<0.05), while 1-hour postprandial blood glucose (1 h PBG) in the control group was significantly higher than before treatment, and 1 h PBG in the observation group was significantly lower than before treatment, with statistical significances (P<0.05). After treatment, FBG, 1 h PBG and 3 h PBG in the observation group were significantly lower than those in the control group (P<0.05). After treatment, the positive symptoms and simple psychopathology scores were lower than those before treatment, while the negative symptoms scores were higher than those before treatment, and the differences were statistically significant (P<0.05). There were no significant differences in positive symptoms, negative symptoms and simple psychopathology scores between the two groups before and after treatment (P>0.05). The quality of life scores such as physical, psychological, social environment and spiritual in the two groups after treatment were significantly higher than those before treatment, and the scores in the observation group were significantly higher than those in the control group, the differences were statistically significant (P<0.05). Conclusion In the course of treatment for schizophrenia, Risperidone and Clozapine both have significant therapeutic effect. However, compared with Clozapine, Risperidone has less effect on blood sugar level and with higher quality of life, which is worthy of clinical promotion and implementation.