益气化聚法联合常规疗法治疗代谢综合征微量白蛋白尿的临床研究

Clinical Study on the Treatment of Metabolic Syndrome Coupled with Microalbuminuria by Combination of Yi Qi Hua Ju Fomula and Western Medicine

目的:探讨在降压、降糖治疗的基础上加载益气化聚法治疗代谢综合征微量白蛋白尿症的临床疗效。方法:代谢综合征微量白蛋白尿症患者60例,随机分为治疗组(常规西药治疗+益气化聚方) 30例与对照组(常规西药治疗+安慰剂) 30例,疗程为12周。观察:尿微量白蛋白、尿微量白蛋白/尿肌酐、24 h尿蛋白定量,体质指数、腰围、腰臀比,HOMA-IR、血糖、血脂、血压等变化情况。结果:治疗后,治疗组在尿液相关指标(尿微量白蛋白、尿微量白蛋白/尿肌酐比值和24 h尿蛋白定量)、形体体征指标(腰围、腰臀比、体质指数)、血压(收缩压、平均动脉压)、血糖(空腹、餐后2 h血糖、HOMA-IR及HbA 1c)及血脂(TG)的改善方面均优于对照组(P <0. 05,P <0. 01)。结论:益气化聚方联合常规西药治疗能有效改善代谢综合征伴微量白蛋白尿症,提高胰岛素敏感性,缓解糖脂代谢紊乱、高血压状态,减轻中心肥胖程度,控制疾病进展。

Objective: To investigate the clinical effect of the treatment of Yi qi Hua Ju formula on metabolic syndrome coupled with microalbuminuria by the basic treatment of anti-hypertensive and anti-diabetic therapy. Methods: 60 cases were randomized into treatment group( western medicine + Yi qi hua ju formula,30 cases) and control group( western medicine + placebo,30 cases) for 12 weeks. The indicators of urine( urinary microalbumin,urinary microalbumin/creatinine ratio and 24-hour urinary protein quantitative),signs indicators( waist circumference,waist-hip ratio,body mass index),blood pressure( systolic blood pressure,diastolic blood pressure,mean arterial pressure),and plasma glucose( fasting plasma glucose,2-hour postprandial plasma glucose,HOMA-IR and HbA 1 c) and blood lipid( TC,TG,LDL,HDL) were compared. Results: After treatment,there were significantly differences in the levels of the urine related indicators( urinary microalbumin,urinary microalbumin/creatinine ratio and 24-hour urinary protein quantitative),signs indicator( waist circumference,waist-hip ratio,body mass index),blood pressure( systolic blood pressure,mean arterial pressure),plasma glucose( fasting plasma glucose,2-hour postprandial plasma glucose,HOMA-IR and HbA 1 c) and blood lipid( TG) between the two groups( P < 0. 05,P < 0. 01). The improvement of those in the treatment group was better than that of the control group. Conclusion: Combined Yi qi hua ju formula and western medicine can effectively improve in patients with metabolic syndrome coupled with microalbuminuria,enhance insulin sensitivity,alleviate glucose,lipid metabolism disorders and hypertension,reduce central obesity and control disease progression.