黄芪注射液对血液透析患者静脉铁剂治疗后氧化应激的影响

Effects of Astragalus Injection on Oxidative Stress After Intravenous Iron Therapy in Hemodialysis Patients

目的:观察黄芪注射液对血液透析患者铁剂治疗后氧化应激的影响。方法:于我血透中心行维持性血液透析治疗并发肾性贫血的患者60例患者纳入研究,采用随机数字表法分为:对照组、治疗组。两组患者除基础治疗外,分别给予铁剂、铁剂+黄芪注射液治疗,每周三次,共十次。观察两组患者治疗后氧化应激指标血清血浆谷胱甘肽过氧化物酶(GSH-Px)、过氧化物歧化酶(SOD)、丙二醛(MDA),贫血和铁代谢指标血红蛋白(Hb)、转铁蛋白饱和度(TSAT)、血清铁蛋白(SF)、铁(Fe)水平的变化。结果:研究完成情况良好,两组患者分组均衡,基线状况良好,可比性强。治疗前GSH-Px、SOD、MDA、Hb、Fe、SF、TSAT差异差异均无明显统计学意义(P> 0. 05);治疗后对照组GSH-Px、SOD较治疗前降低(P <0. 05),MDA较治疗前升高(P <0. 05);治疗后治疗组较对照组GSH-Px、SOD升高,MDA降低,组间比较,差异均有统计学意义(P <0. 05);治疗组较对照组Hb、TSAT、SF、Fe明显升高,在改善贫血方面,治疗组疗效优于对照组(P <0. 05)。结论:黄芪注射液可一定程度上改善血液透析患者静脉铁剂治疗后氧化应激状态,提高纠正贫血疗效。

Objective: To observe the effects of astragalus injection on oxidative stress after iron therapy in hemodialysis patients. Methods: Sixty patients with renal anemia complicated by maintenance hemodialysis were included in the study. Patients were divided into controlgroup,treatment group. In addition to the foundation treatment,two groups of patients were given iron,iron + astragalus injection treatment respectively about ten times,three times a week. The changes of two groups patients after treatment in oxidative stress indicators GSH-px,SOD,MDA and in anemia and iron metabolism indicators Hb,TSAT,SF,Felevels were observed.Results: The study was completed well,the two groups of patients were well balanced,the baseline condition was good,and the comparabilitywas strong. Before treatment,there were no statistically significant differences in GSH-px,SOD,MDA,HB,TSAT,SFand Fe( P > 0. 05). GSH-pxand SOD were decreased in controlgroup after treatment( P < 0. 05),while MDA was increased( P < 0. 05).After treatment,GSH-px and SOD increased and MDA decreased in treatmentgroup compared with controlgroup( P < 0. 05). The effect of treatmentgroup was significantly higher than that of control group in HB,TSAT,SF,Fe,and the effect of treatment group was better than that of control group( P < 0. 05). Conclusion: Astragalus injection can reduce oxidative stress and improve the effect of anemia treatment in hemodialysis patients.