3,3’-二氨基-4,4’-二羟基二苯砜的合成

Preparation of the 3,3’-Diamino-4,4’-dihydroxydiphenyl Sulfone

3,3'-二硝基-4,4'-二氯二苯砜与氢氧化钠在二甲基亚砜中85℃反应得到3,3'-二硝基-4,4'-二羟基二苯砜,再经铁粉/氯化铵50℃下经还原反应得到3,3'-二氨基-4,4'-二羟基二苯砜,总收率74%。该路线具有收率高,原材料易得,环境友好等优点。

3,3'-dinitro-4,4'- dichlorodiphenyl sulfone react with sodium hydroxide in DMSO 85℃ to get3,3'-dinitro-4,4'- dihydroxydiphenyl sulfone;then react with iron and ammonium chloride to get3,3'-diamino-4,4'- dihydroxydiphenyl sulfone,the total yield was 74%. This route has high yield,easy to buy raw materials,environment friendly,etc.