尼古丁对骨骼系统影响及机制研究进展

Effects of nicotine on the skeletal system and the research progress

尼古丁(C10H14N2)是从烟草植物中衍生的植物生物碱,是烟草的主要成分。吸烟时尼古丁通过黏膜进入血液系统,以游离形式分布到机体其他组织,通过促进神经递质的释放、减少抗体产生、影响外周免疫功能及钙磷代谢造成机体多系统产生损害。本文就尼古丁对骨骼系统的影响及机制研究进展进行总结,为今后研究尼古丁对骨质疏松、骨折、口腔种植体、人工关节的影响及尼古丁的戒断反应提供线索。

Nicotine (C10H14N2) is a plant alkaloid derived from tobacco plants and is the main component of tobacco. When smoking, nicotine enters the blood system through the mucous membranes and is distributed in free form to other body tissues. It causes damage to multiple systems of the body by promoting the release of neurotransmitters, reducing antibody production, affecting peripheral immune functions and calcium and phosphorus metabolism. This article summarizes the research progress in the effect of nicotine on the skeletal system and the mechanism, and provides clues for the future study of the effect of nicotine on osteoporosis, fractures, oral implants, artificial joints, and withdrawal reaction of nicotine.