中医治疗脑卒中后抑郁症处方特征的综合分析

Comprehensive Analysis on the Prescription Characteristics of Traditional Chinese Medicine in the Treatment of Post-stroke Depression

目的分析脑卒中后抑郁症治疗方剂的处方特征及用药规律。方法检索中国医院知识仓库信息系统近13年的文献资料,并进行统计分析。结果50篇论文中使用疏肝理气30张,活血通络方9张,理气化痰方7张,补益肝肾类4张。103味中药中,健脾运中、理气解郁、化痰开窍及活血通络类使用频繁,总频次位列前4位。处方使用频数较高的23种中药,分别为柴胡、川芎、白芍、石菖蒲、郁金、香附、甘草、枳壳、当归、远志等。当归+丹参、远志+夜交藤、当归+夜交藤等对药常配伍组合。按关联规则算法,提示解郁柔肝、化痰开窍及活血通络药物配伍的概率较高。结论中医治疗脑卒中后抑郁症的处方以健脾运中、理气解郁、化痰开窍、活血通络为主,结合安神定志等,兼顾其他病理因素,反映出脑卒中后抑郁的治疗处方有其自身的特点。

Objective To analyze the prescription characteristics and medication rules of treatment prescriptions for post-stroke depression. Methods The data of Chinese hospital knowledge warehouse information system in recent 13 years were retrieved and analyzed statistically. Results Among the 50 papers, 30 were used for soothing liver and regulating qi, 9 for promoting blood circulation and dredging collaterals, 7 for regulating qi and phlegm, and 4 for tonifying liver and kidney. Among 103 traditional Chinese medicines, Spleen-strengthening and transporting, regulating qi to relieve depression, resolving phlegm and opening orifices, activating blood circulation and dredging collaterals were frequently used, and the total frequency ranked the top four. Among 103 traditional Chinese medicines, spleen-strengthening and transporting, regulating qi to relieve depression, resolving phlegm and opening orifices, activating blood circulation and dredging collaterals were frequently used, and the total frequency ranked the top four. Twenty-three kinds of traditional Chinese medicines with high frequency were prescribed, including Bupleurum, Ligusticum chuanxiong, Paeonia lactiflora, Acorus calamus, Tulip, Cyperus, Licorice, Fructus Aurantii, Angelica sinensis and Polygala. Radix Angelicae Sinensis and radix salviae miltiorrhizae, Radix Polygalae, Caulis Polygoni Multiflori, Radix Angelicae Sinensis and Caulis Polygoni Multiflori. According to the association rule algorithm, the probability of dispelling depression and softening liver, resolving phlegm and inducing resuscitation and promoting blood circulation and dredging collaterals is higher. Conclusion The prescriptions of TCM for treating post-stroke depression mainly include invigorating the spleen, regulating qi and relieving depression, resolving phlegm, activating blood circulation and dredging collaterals, taking into account other pathological factors, reflecting that the prescriptions for treating post-stroke depression have their own characteristics.