中药益气活血方对急诊PCI患者的氧化应激水平的影响

Efficacy of the Yiqi Huoxue prescription on oxidative stress level of PCI patients in emergency

目的:研究中药益气活血方对急诊经皮冠状动脉支架置入术(Percutaneous Transluminal Coronary Intervention,PCI)患者的氧化应激水平的影响。方法:选择我院收治的急性ST段抬高型心肌梗死并行急诊PCI术的患者118例;应用随机数字表法分为对照组和治疗组,每组59例,对照组在行急诊PCI术后给予常规药物治疗,治疗组在行急诊PCI术后常规治疗的基础上再给予中药益气活血方。比较两组患者入院即刻和急诊PCI术后48h、7d、2周的血清中氧化应激相关因子[超氧化物歧化酶(Superoxide Dismutase,SOD)、谷胱甘肽过氧化物酶(Glutathione Peroxidase,GSH-Px)和丙二醛(Malondialdehyde,MDA)]。结果:治疗组较对照组入院即刻差异无统计学意义(P>0.05);支架置入术后48h、7d、2周的水平差异均有统计学意义(P<0.05)。结论:中药益气活血方能有效改善急诊PCI术患者的氧化应激水平。

Objective: To observe efficacy of the Yiqi Huoxue prescription (益气活血方) on oxidative stress level of PCI patients in emergency. Methods: 118 patients were randomly divided into the treatment group and control group, 59 cases in each group. The control group received conventional medicine. The treatment group was given the Yiqi Huoxue prescription more. Results: The serum superoxide dismutase and glutathione peroxidase were more increased, and malondialdehyde was more decreased in 48 hours, 7 days and 2 weeks in the study group (P <0.05). Conclusion: The Yiqi Huoxue prescription on oxidative stress level was effective.