重症急性胰腺炎的中医病机及后期治疗的临床分析

A clinical analysis of TCM pathogenesis and post-treatment of severe acute pancreatitis

目的:探究重症急性胰腺炎的中医病机与后期治疗效果。方法:对62例重症急性胰腺炎患者进行分析,随机分为对照组31例(采用常规治疗)与实验组31例(采用中医治疗),对比两组治疗效果。结果:实验组患者治疗总有效率为93.5%,明显优于对照组的77.4%,对比差异显著,具有统计学意义(P<0.05)。另外,实验组患者腹痛消失时间、肛门排气时间、血淀粉酶恢复正常时间、血钙恢复正常时间、体温恢复正常时间、首次排便时间均明显优于对照组,差异显著,P<0.05,具有统计学意义。两组患者治疗前与治疗后在白细胞计数、血淀粉酶水平与胃肠功能评分对比中,差异存在统计学意义,且治疗后实验组患者在白细胞计数、血淀粉酶水平与胃肠功能评分中明显优于对照组,差异存在统计学意义,P<0.05。治疗前与治疗后,两组患者在白细胞介素-8(Interleukin-8,IL-8)、肿瘤坏死因子-α(Tumor Necrosis Factor,TNF-α)、超敏C反应蛋白(highsensitivity C-reactive Protein,hs-CRP)指标对比中,差异存在统计学意义;治疗后,实验组在IL-8、TNF-α、hs-CRP指标对比中,明显优于对照组,P<0.05。结论:重症急性胰腺炎患者使用中医治疗能够显著提升预后效果,改善症状,可以取得满意的治疗效果,具有较高的临床应用价值。

Objective: To explore the effect of TCM pathogenesis and post-treatment on severe acute pancreatitis. Methods: 62 patients with severe acute pancreatitis were randomly divided into the control group (31 cases, given conventional treatment) and the experimental group (31 cases, given TCM). The therapeutic effects were compared between two groups. Results: The total efficiency in the experimental group was 93.5%, was significantly better than 77.4% in the control group (P<0.05). In the experimental group, the disappearance time of abdominal pain, the time of anal exhaust, the normal time of blood amylase recovery, the normal time of blood calcium recovery, the normal time of body temperature recovery, and the first defecation time were significantly better than the control group, P<0.05. There were statistically significant differences in two groups in white blood cell count, blood amylase level and gastrointestinal function score between before and after treatment, and those in the experimental group were better, P<0.05. Between before and after treatment, the difference in IL-8, TNF-α and hs-CRP in two groups was statistically significant. And those in the experimental group were better, P<0.05. Conclusion: TCM on severe acute pancreatitis was effective, can improve the prognosis of patients and symptoms, with high clinical application value.