大剂量阿托伐他汀对急性脑梗死患者神经功能及NF-κB、IL-6表达的影响

Effects of high dose atorvastatin on nerve function and expression of NF- kappa B and IL-6 in patients with acute cerebral infarction

目的 探讨大剂量阿托伐他汀对急性脑梗死患者神经功能及核因子-κB(Nuclear transcription factor-κB,NF-κB)、白介素-6(Interleukin-6,IL-6)水平的影响。方法 回顾性分析2017年2月至2018年8月在本院接受阿托伐他汀治疗的72例急性脑梗死患者的临床资料,依据药物使用剂量的不同,分为常规剂量组(36例)与大剂量组(36例),比较两组NF-κB、IL-6与美国国立卫生研究院卒中量表(NIH Stroke Scale,NIHSS)评分。结果 治疗前,两组NF-κB与IL-6水平及NIHSS评分对比,差异无统计学意义(P>0.05);治疗14d后,大剂量组NF-κB与IL-6水平分别为(0.54±0.13)ng/L、(115.32±16.97)ng/L,均低于常规剂量组的(0.69±0.12)ng/L、(131.12±18.95)ng/L,差异有统计学意义(P<0.05);治疗7d、14d、21d后,大剂量组NIHSS评分分别为(9.19±3.15)分、(8.51±2.03)分、(5.78±1.39)分,均低于常规剂量组的(14.75±3.44)分、(14.53±3.16)分、(13.14±3.05)分,差异有统计学意义(P<0.05)。结论 急性脑梗死患者经大剂量阿托伐他汀治疗,可有效缓解炎症反应,提高神经功能。

Objective To study the effect of high-dose atorvastatin on nerve function and the levels of nuclear transcription factor-κB (NF-κB) and interleukin-6 (IL-6) in patients with acute cerebral infarction. Methods The clinical data of 72 patients with acute cerebral infarction treated by atorvastatin in our hospital from February 2017 to August 2018 were analyzed retrospectively, who were divided into routine dose group (36 cases) and high dose group (36 cases). NF-κB, IL-6 and NIH Stroke Scale (NIHSS) score were compared between the two groups. Results Before treatment, there were no statistically significant differences in the levels of NF-κB and IL-6 and NIHSS score between the two groups (P>0.05);after 14 days of treatment, the levels of NF-κB and IL-6 in the high dose group were (0.54±0.13) ng/L,(115.32±16.97) ng/L, which were lower than those of the normal dose group [(0.69±0.12) ng/L,(131.12±18.95) ng/L], with statistically significant differences (P<0.05). On the 7th, 14th, and 21st day after treatment, the NIHSS score in the high-dose group were (9.19±3.15),(8.51±2.03), and (5.78±1.39), respectively, which were lower than those in the conventional dose group [(14.75±3.44),(14.53±3.16),(13.14±3.05)], with statistically significant differences (P<0.05). Conclusion High dose of atorvastatin can effectively relieve inflammatory reaction and improve neurological function in patients with acute cerebral infarction.