重组人干扰素联合微波治疗慢性宫颈炎合并高危型HPV感染疗效观察

Therapeutic effect of recombinant human interferon combined with microwave on chronic cervicitis complicated with high-risk HPV infection

目的 观察重组人干扰素联合微波治疗慢性宫颈炎合并高危型人乳头瘤病毒(HPV)感染的疗效。方法 选择2015年7月至2018年6月本院治疗的86例慢性宫颈炎合并高危型HPV感染者,将其应用随机数表法分为两组,各43例。对照组接受微波治疗,观察组接受重组人干扰素、微波联合治疗。观察两组临床疗效、HPV感染转阴率及复发率、不良反应等。结果 观察组总有效率为95.35%,高于对照组79.07%,差异有统计学意义(P<0.05);观察组HPV感染转阴率为65.12%,高于对照组41.86%,HPV感染复发率为4.65%,低于对照组18.60%,差异均有统计学意义(均P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 慢性宫颈炎合并高危型HPV感染患者接受重组人干扰素、微波联合治疗是安全可行的,宫颈糜烂愈合效果良好,有利于提升HPV感染转阴率,降低HPV感染复发率。

Objective To observe the therapeutic effect of recombinant human interferon combined with microwave for chronic cervicitis complicated with high-risk human papillomavirus (HPV) infection. Methods 86 cases of chronic cervicitis complicated with high-risk HPV infection treated in our hospital from July, 2015 to June, 2018 were divided into a control group and an observation group by random number table, 43 cases for each group. The control group received microwave treatment, while the observation group recombinant human interferon and microwave treatment. The clinical efficacy, negative conversion rate of HPV infection, recurrence rate, and adverse reactions of the two groups were observed. Results The total effective rate and negative rate of HPV infection were higher and the recurrence rate of HPV infection was lower in the observation group than in the control group (95.35% vs. 79.07%, 65.12% vs. 41.86%, 4.65% vs. 18.60%)(all P < 0.05). There was no statistical difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion The combination of recombinant human interferon and microwave is safe and feasible for patients with chronic cervicitis complicated with high-risk HPV infection. The healing effect of cervical erosion is good, which is conducive to improving the negative conversion rate of HPV infection and reducing the recurrence rate of HPV infection.