盐酸右美托咪定在机能学实验“氨中毒引起肝性脑病及精氨酸治疗效果”中的应用研究

Application of dexmedetomidine hydrochloride in functional experiment "hepatic encephalopathy caused by ammonia poisoning and treatment effect of arginine"

“氨中毒引起肝性脑病及精氨酸治疗效果”是医学机能学实验项目之一,常规在普鲁卡因局部浸润麻醉下实施腹部手术。因麻醉效果欠佳,术中动物因疼痛而剧烈挣扎,致腹腔内容物频繁溢出,不仅影响手术的顺利进行,也给动物带来极大伤害,给老师和学生带来较大心理负担。本实验在对家兔实施皮下注射普鲁卡因浸润麻醉前,辅以耳缘静脉注射盐酸右美托咪定,探讨保证在家兔安静状态下顺利完成上腹部手术,同时不影响氨的中枢毒性作用的效果观察。

"Hepatic encephalopathy caused by ammonia poisoning and treatment effect of arginine" is one of the experimental items of medical mechanics. Abdominal surgery is routinely performed under local infiltration anesthesia with procaine.Due to the poor anesthesia effect, the animals struggled violently due to pain during the operation, resulting in frequent spillage of abdominal contents, which not only affected the smooth operation, but also brought great harm to the animals and brought great psychological burden to teachers and students. In this study, dexmedetomidine hydrochloride was injected into the ear margin before subcutaneous injection of procaine infiltration anesthesia in rabbits,and to discuss the observation of ensuring the successful completion of the upper abdomen operation in the quiet state of rabbits without affecting the central toxic effect of ammonia, and the effect was better.