肾素-血管紧张素系统在骨关节炎发病中的研究

Renin-angiotensin system in pathogenesis of osteoarthritis

骨关节炎是一种以关节软骨退变为主的慢性疾病,但其具体发病机制目前仍不清楚。肾素-血管紧张素系统在维持人体内部环境的稳定中起着重要作用,近年来也被认为在骨关节炎的发生、发展中发挥重要的调控作用。本文针对肾素-血管紧张素系统信号通路调控骨关节炎及退变的分子机制进行综述。

Osteoarthritis (OA) is a chronic disease in which articular cartilage is regressed, but its specific pathogenesis is still unclear. The renin-angiotensin system (RAS) plays an important role in maintaining the stability of the internal environment of the human body. In recent years, it has also been recognized as an important regulatory signal network of osteoarthritis, playing an important regulatory role in the occurrence and development of osteoarthritis. This article reviewed the molecular mechanism of RAS signaling pathway regulation of osteoarthritis and degeneration.