腺苷酸活化蛋白激酶在脑缺血中的作用及其机制

Roles and mechanisms of adenosine monophosphate activated protein kinase in cerebral ischemia

腺苷酸活化蛋白激酶(AMPK)是一种高度保守的丝氨酸/苏氨酸蛋白激酶,在能量代谢的调控中起重要作用。脑缺血、缺氧后可激活AMPK,活化的AMPK通过抑制氧化应激和炎性反应、激活自噬、减轻细胞凋亡和促进血管生成等机制,减轻脑缺血后的神经功能损伤,从而发挥神经保护作用。作者对AMPK的分子生物学特征及其在脑缺血中的作用及机制进行了综述,目的在于促进对AMPK的深入研究,使其成为缺血性卒中治疗的一个新靶点。

Adenosine monophosphate activated protein kinase(AMPK) is a highly conserved serine/threonine protein kinase which plays an important role in regulating energy metabolism. After cerebral ischemia and hypoxia,AMPK is activated. The activation of AMPK could decrease neurological impairment after cerebral ischemia and plays a neuroprotective role by mechanisms such as inhibiting oxidative stress and inflammation,activating autophagy,alleviating apoptosis and promoting angiogenesis.This article reviews the molecular biological characteristics of AMPK and its role and mechanism in cerebral ischemia, aiming to promote an in-depth study of AMPK and make it a novel target for the treatment of ischemic stroke.