鼻塞式同步间歇指令通气联合肺表面活性物质治疗新生儿肺透明膜病的临床研究

Clinical Study of Nasal Synchronous Intermittent Ventilation Combined with Pulmonary Surfactant in the Treatment of Neonatal Hyaline Membrane Disease

目的探讨鼻塞式同步间歇指令通气联合肺表面活性物质治疗新生儿肺透明膜病的效果。方法以2016年1月-2017年10月郑州大学第三附属医院接收的108例肺透明膜病新生患儿为例,随机分成对照组(54例)和研究组(54例)。对照组采用鼻塞式持续气道正压通气(nCPAP)联合肺表面活性物质(PS)治疗,研究组采用鼻塞式同步间歇指令通气(nSIMV)联合PS治疗,比较两组的血气分析指标和并发症发生情况。结果研究组PaO2、SpO2均显著高于对照组,PaCO2显著低于对照组,且研究组并发症总发生率显著低于对照组(P<0.05)。结论nSIMV联合PS治疗新生儿肺透明膜病的效果显著,并能有效减少并发症的发生。

Objective To investigate the effect of nasal intermittent synchronous ventilation combined with pulmonary surfactant on neonatal hyaline membrane disease.Methods A total of 108 neonatal children with hyaline membrane disease adimitted in our hospital from January 2016 to October 2017 were randomLy divided into the control group (54 cases) and the study group (54 cases).The control group was treated with nasal continuous positive airway pressure ventilation(nCPAP) combined with pulmonary surfactant (PS) treatment,while the study group used nasal congestion synchronous intermittent mandatory ventilation (nSIMV) combined with PS treatment.Compared the blood gas analysis indicators and complications between the two groups.Results PaO2 and SpO2 in the study group were significantly higher than those in the control group.PaCO2 was significantly lower than the control group,and the total incidence of complications in the study group was significantly lower than that in the control group (P < 0.05).Conclusion nSIMV combined with PS is effective in the treatment of neonatal hyaline membrane disease,and can effectively reduce the occurrence of complications.