肠内营养乳剂联合胸腺肽α1在老年COPD急性加重期的应用效果

Application effect of enteral nutrition emulsion combined with thymosin α1 in elderly patients with acute exacerbation of COPD

目的研究肠内营养乳剂(TPF-T)联合胸腺肽α1在老年慢性阻塞性肺疾病(COPD)急性加重期的应用效果。方法将66例老年COPD急性加重期患者随机分为对照组和联合组,各33例。对照组在对症治疗的基础上给予胸腺肽α1,联合组在对照组基础上给予TPF-T。比较两组治疗效果。结果治疗后,两组血清CC16、SP-D水平均降低,FEV1、FEV1/FVC均升高,且联合组优于对照组(P<0.05)。联合组的治疗总有效率显著高于对照组(P<0.05)。结论 TPF-T联合胸腺肽α1应用于老年COPD急性加重期有利于改善患者的生物标志物水平,促进肺功能恢复,提高治疗效果。

Objective To study the application effect of enteral nutrition emulsion(TPF-T) combined with thymosin α1 in elderly patients with acute exacerbation of chronic obstructive pulmonary disease(COPD). Methods A total of 66 elderly patients with acute exacerbation of COPD were randomly divided into control group and combined group, with 33 cases in each group. The control group was given thymosin α1 on the basis of the symptomatic treatment, and the combined group was given TPF-T on the basis of the control group. The therapeutic effects of the two groups were compared. Results After treatment, the levels of serum CC16 and SP-D in both groups decreased, while the FEV1 and FEV1/FVC increased, and those of the combined group were better than the control group(P <0.05). The total effective rate of teratment in the combined group was significantly higher than that in the control group(P<0.05). Conclusion The application of TPF-T combined with thymosin α1 in elderly patients with acute exacerbation of COPD can improve the levels of biomarkers,promote the recovery of pulmonary function and improve the therapeutic effect.