磷酸奥司他韦治疗小儿甲型H1N1流感的效果及安全性

Effect and safety of oseltamivir phosphate in the treatment of influenza A (H1N1) in children

目的探讨磷酸奥司他韦治疗小儿甲型H1N1流感的效果及安全性。方法将我院收治的86例甲型H1N1流感患儿按抽签方式随机分为对照组和观察组,每组43例。对照组给予利巴韦林治疗,观察组给予磷酸奥司他韦治疗,比较两组临床疗效及不良反应发生情况。结果观察组症状缓解时间、发热持续时间、病毒核酸阳性持续时间均显著短于对照组(P<0.05);治疗后,两组体温均低于治疗前(P<0.05)。两组患儿不良反应总发生率比较,差异无统计学意义(P>0.05)。结论磷酸奥司他韦治疗小儿甲型H1N1流感效果显著,且安全性较高,值得推广。

Objective To explore the effect and safety of oseltamivir phosphate in the treatment of influenza A(H1 N1) in children. Methods Eighty-six children with influenza A(H1 N1) admitted in our hospital were randomly divided into control group and observation group by drawing lots method, with 43 cases in each group. The control group was treated with ribavirin, and the observation group was treated with oseltamivir phosphate. The clinical efficacy and adverse reactions between the two groups were compared. Results The symptoms relief time, fever duration and viral nucleic acid positive duration in the observation group were significantly shorter than those in the control group(P<0.05);after treatment, the body temperature in the two groups were lower than those before treatment(P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(P >0.05). Conclusion Oseltamivir phosphate in the treatment of influenza A(H1 N1) in children has a significant effect and high safety, which is worthy of promotion.